We used CdSe/ZnS quantum dots-ssDNA-fluorescent dye conjugates as bioprobes to detect micrococcal nuclease with high specificity and sensitivity, and further utilized the bioprobe to monitor the micrococcal nuclease activity in the culture medium of Staphylococcus aureus by fluorescence microscopy.

From molecular design principles to biological applications, we systematically summarized the development of activatable AIE bioprobes in recent years. Additionally, challenges probes and corresponding solutions are described. We hope that information provided this review will facilitate more promote practical application AIEgens. (Aggregate. 2021;2:e51)

2 Structures for Nanoelectronic Bioprobes 3 Lin Xu,†,‡,§ Zhe Jiang,‡,§ Quan Qing,‡,§ Liqiang Mai,† Qingjie Zhang,† and Charles M. Lieber*,†,‡,∥ 4 †WUT-Harvard Joint Nano Key Laboratory, State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, 5 Wuhan University of Technology, Wuhan 430070, China 6 ‡Department of Chemistry and Chemical Biology and School of Engineering...

BACKGROUND Paired with satellite location telemetry, animal-borne instruments can collect spatiotemporal data describing the animal's movement and environment at a scale relevant to its behavior. Ecologists have developed methods for identifying the area(s) used by an animal (e.g., home range) and those used most intensely (utilization distribution) based on location data. However, few have ext...

A one-step homogeneous colorimetric immunoassay format coupled with zeta potential measurements for determination of specific diabetic biomarker glycated hemoglobin (HbA1c) using functionalised gold nanoparticles as bioprobes is reported. The assay exhibited an excellent sensitivity based on absorbance and zeta potential measurements showing the dynamic response range from 0.001-0.004 mg mL(-1)...

Haptoglobin (Hp) is an acute phase protein that binds free hemoglobin (Hb), preventing Hb-induced oxidative damage in the vascular system. There are three phenotypes in human Hp, whose heterogeneous polymorphic structures and varying concentrations in plasma have been attributed to the cause of diseases and outcome of clinical treatments. Different phenotypes of Hp may be composed of the same s...

Lanthanide bioprobes and bioconjugates are ideal luminescent stains in view of their low propensity to photobleaching, sharp emission lines and long excited state lifetimes permitting time-resolved detection for enhanced sensitivity. We show here how the interplay between physical, chemical and biochemical properties allied to microfluidics engineering leads to self-assembled dinuclear lanthani...