نتایج جستجو برای: bithiazoles
تعداد نتایج: 12 فیلتر نتایج به سال:
Bacterial DNA gyrase is a well-established and validated target for the development of novel antibacterials. Starting from the available structural information about the binding of the natural product inhibitor, clorobiocin, we identified a novel series of 4'-methyl-N(2)-phenyl-[4,5'-bithiazole]-2,2'-diamine inhibitors of gyrase B with a low micromolar inhibitory activity by implementing a two-...
There are several lines of evidence indicating that the DNA-cleaving activity of bleomycin determines its cytotoxicity. (1) Most bleomycin analogs and derivatives which degrade isolated DNA are also active against living cells and vice versal) ; (2) some bacterial mutants selected for sensitivity to bleomycin lacked DNA-repair systems',') ; and (3) more degradation of DNA was observed in cells ...
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