Background: Basaloid follicular hamartomas (BFHs) may occur as single isolated tumors, as localized tumors or as multiple tumors in a disseminated or in a patterned distribution. Non-hereditary multiple and mostly unilateral basaloid follicular hamartomas arranged according to Blaschko`s lines with associated extracutaneous malformations have been designated as a genetic mosaicism disease and o...

Blaschko-linear psoriasis (PBL) is a rare form of that presents as longitudinal lines on the skin, along Blaschko lines. This often observed in children and can be difficult to distinguish from other acquired linear dermatoses such inflammatory verrucous epidermal nevus (ILVEN) lichen striatus. The prevalence PBL unknown, but it generally more common boys than girls. clinical histological simil...

Focal dermal hypoplasia (FDH) is a rare genetic skin disorder. The inheritance of FDH or Goltz-Gorlin syndrome is X-linked dominant and the disease is associated with a PORCN gene mutation. This gene plays a key role in the Wnt pathway, which has an impact on embryonic development. Every tissue derived from meso- and ectoderm can be affected. Patients suffer from cutaneous, ocular, osseous, ora...

Atypical and unusual locations of psoriasis are very frequent. However, localized linear psoriasis is rare, with few cases described in the literature. It is characterized by a linear distribution of psoriasis lesions along Blaschko lines. We report the case of a three years old child, who presented unilateral erythematous scaly plaques arranged along Blaschko lines in the left hemithorax, with...

Linear psoriasis is an unusual clinical variation of psoriasis that manifests segmentally along the lines of Blaschko. A major differential diagnosis is inflammatory linear verrucous epidermal nevus (ILVEN). The treatment of linear psoriasis is often challenging, with inadequate response to biological agents reported in the literature. We report a case of a 25-year-old African-American female w...

Linear acantholytic dermatoses are a spectrum of cutaneous disorders that form a subset of linear dermatoses with distinct clinical features and histopathologically show acantholysis. The lesions may be zosteriform or follow the lines of Blaschko. This report describes a four-year-old boy who, on a follow up of two years, exhibited a relapsing acantholytic dermatosis along the lines of Blaschko...

Actas Dermosifiliogr. 2009;100:329-43 341 13. Boswell JS, Davis MD. Violaceous plaque on the forehead clinically resembling angiosarcoma: cutaneous metastasis in a patient with prostatic adenocarcinoma. J Am Acad Dermatol. 2005;53:744-5. 14. Sharma R, Chandra M. Cutaneous metastases from carcinoma of the prostate: a case report. Dermatol Online J. 2005;11:24. 15. Fukuda H, Saito R. A case of Si...

Lichen planus is an uncommon disease in children, and only 2 to 3% of affected patients are under twenty years of age. This dermatosis may appear in several clinical forms, which vary according to the morphology and distribution of lesions. In less than 0.2% of all lichen planus cases, the lesions are distributed along the lines of Blaschko, and is a variant called linear lichen planus. This is...

A mosaic is an organism composed of two or more genetically distinct cell populations derived from a genetically homogeneous zygote. Cutaneous mosaicisms are the clinical expressions of these disorders. The main event which allows the existence of mosaicism is a genetic mutation, either structural or functional. Cutaneous mosaicisms usually manifest by specific patterns on the skin and the arch...