purpose: to compare the success rate of mitomycin-c versus bevacizumab for prevention of bleb failure following phacotrabeculectomy. method: in this study 74 eyes of 69 patients with uncontrolled iop, progressive visual field loss and cataract were randomized in two groups. in the first group, after conjunctival peritomy at the sclera flap site, sponge pats soaked in mitomycin c with concentrat...

the most common cause of failure during the first trimester after trabeculectomy is encapsulated bleb and needling bleb revision is a less invasive method in the management of refractory cases. the purpose of this study is to determine the efficacy and safety of mitomycin-c (mmc) augmented bleb revision of failed filtration surgery. this study is a before-after (paired) observation. 33 patients...

PURPOSE OF REVIEW To present a review of the current literature regarding the management of glaucoma-filtering bleb infections. RECENT FINDINGS With the increased use of intraoperative antifibrotic (eg, mitomycin and fluorouracil) as an adjunct to standard trabeculectomy, an increased incidence is seen of late-onset filtering bleb-related infections. These infections range from infections loc...

PURPOSE To report a case of autologous transplantation of a free Tenon's graft to repair excessive bleb leakage after trabeculectomy. CASE REPORT A 39-year-old Japanese woman presented with severe hypotony in her left eye. She had undergone trabeculectomy with mitomycin C 14 years ago. Slit-lamp examination showed an ischemic and ruptured bleb, excessive bleb leakage, and an extremely shallow...

Introduction: Primary open angle glaucoma is a symptom complex wherein there is damage to the optic nerve head with characteristic morphological and functional alterations in Optic Nerve Head (ONH). Aim: To compare the recent surgical approach minitrab with conventional trabeculectomy with reference to post-operative success. Materials and Methods: This prospective study was done in Theni Medic...

PURPOSE To evaluate the 5-year incidence rate of blebitis and bleb-associated endophthalmitis in the United States. METHODS In this retrospective cross-sectional study, we utilized a large commercial health insurance claim-based database during 2007-2011 and identified all patients who had a record of trabeculectomy in 2007. These patients were followed until the end of 2011. During the follo...

BACKGROUND Glaucoma surgery is the most effective means for lowering intraocular pressure by providing a new route for fluid to exit the eye. This new pathway is through the sclera of the eye into sub-conjunctival tissue, where a fluid filled bleb typically forms under the conjunctiva. The long-term success of the procedure relies on the capacity of the sub-conjunctival tissue to absorb the exc...

Objective: To determine the effect of intravitreally administered bevacizumab, alone or as adjunct to mitomycin-C, after trabeculectomy on bleb survival and histology in rabbit eyes. Methods: An experimental, interventional, comparative, animal study consisting of 16 rabbit eyes underwent trabeculectomy, 8 of which were enhanced with intra-operative mitomycin-C. Eyes were randomized to receive ...

PURPOSE To report a case of inadvertent bleb formation presenting 18 months after pars plana M3 Molteno implant tube obstruction in a patient with mixed mechanism glaucoma. MATERIALS AND METHODS An 84-year-old Caucasian male with mixed mechanism glaucoma underwent slit-lamp examination, gonioscopy, colour anterior segment photography and anterior segment optical coherence tomography (AS-OCT)....

Blebs are spherical membrane protrusions often observed during cell migration, cell spreading, cytokinesis, and apoptosis, both in cultured cells and in vivo. Bleb expansion is thought to be driven by the contractile actomyosin cortex, which generates hydrostatic pressure in the cytoplasm and can thus drive herniations of the plasma membrane. However, the role of cortical tension in bleb format...