The bleeding time is currently the only clinically available comprehensive test to explore primary hemostasis. It is currently performed mostly as a screening procedure before surgery, to detect otherwise unknown defects in platelet-vessel wall interactions, but its use in this specific setting has been seriously questioned by recent reanalyses of previously published literature. We studied the...

background: the main cause of discontinuing the use of depomedroxy progesterone acetate (dmpa) is irregular bleeding. this study compared placebo with two kinds of combined oral contraceptive pills including low dose (ldocp) and high dose (hdocp) on control of abnormal uterine bleeding in dmpa users. methods: ninety dmpa users complaining of bleeding were studied in a triple blind randomized cl...

AIMS The aim of this study was to compare the effects of aspirin on platelet function as measured by the 'classical' template bleeding time with a new ex vivo method measuring closure times using the PFA-100 machine. Platelet aggregation in response to arachidonic acid was also measured ex vivo. METHODS The trial was a randomized, double-blind, placebo-controlled crossover design, with each v...

OBJECTIVE We aimed to determine the efficacy and safety of early (within the first 24 hour from application) endoscopy and colonoscopy in very elderly patients with GIS bleeding. METHODS In this study, 95 patients were included who underwent early endoscopy with the pre-diagnosis of upper GIS bleeding or endoscopy-colonoscopy with the pre-diagnosis of lower GIS bleeding between 2012 and 2016....

OBJECTIVES Corticosteroids are frequently used in a range of otorhinolaryngologic conditions due to their anti-inflammatory and antiedematous properties. In this meta-analysis, we aimed to assess the role of preoperative steroids for attenuating intraoperative bleeding during endoscopic sinus surgery among patients with nasal polyps. DATA SOURCES PubMed, SCOPUS, EMBASE, the Web of Science, an...

Magnesium sulfate is widely used in obstetrics and is drug of choice in two important complications of pregnancy, preeclampsia and preterm labor. The antagonistic effects of magnesium sulfate on calcium ion and on platelet aggregation may lead to changes in bleeding time. This study was conducted to evaluate the effect of magnesium sulfate on bleeding time in women with threatened preterm labor...

Mezlocillin was compared with carbenicillin and 0.9% NaCl as placebo in a double-blind manner to determine its effect in vivo on hemostasis in normal volunteers. Eighteen subjects were randomized to receive mezlocillin, 4 g every 6 h; carbenicillin, 7.5 g every 6 h; or placebo, 50 ml every 6 h, each given for 20 intravenous doses unless the template bleeding time after 10 doses was greater than...