Objective(s): In this work, electrospun nanofibers were explored as drug delivery vehicles using tetracycline as a model drug.  Nanocomposite fibers including chitosan (CS)/poly (ethylene oxide) (PEO) and antibiotic were successfully prepared using electrospinning. CS blended with PEO considering a weight ratio of (90/10), and then, nanofibrous samples were successfully e...

BACKGROUND Rotator cuff tears are a common and frequent lesion especially in older patients. The mechanisms of tendon repair are not fully understood. Common therapy options for tendon repair include mini-open or arthroscopic surgery. The use of growth factors in experimental studies is mentioned in the literature. Nanofiber scaffolds, which provide several criteria for the healing process, mig...

The Poly (vinyl alcohol)/Kefirane nanofiber membrane was successfully fabricated for the firsttime using electrospinning of the polyvinyl alcohol (PVA) and Kefirane blend solution. Scanningelectron microscope (SEM), attenuated total reflectance Fourier transform infrared (ATRFT-IR), and differential scanning calorimetry (DSC) were used to characterize the electrospunPoly (vinyl alcohol)/Kefiran...

Electrospinning of collagen and chitosan blend solutions in a 1,1,1,3,3,3-hexafluoroisopropanol/trifluoroacetic acid (v/v, 90/10) mixture was investigated for the fabrication of a biocompatible and biomimetic nanostructure scaffold in tissue engineering. The morphology of the electrospun collagen-chitosan nanofibers was observed by scanning electron microscopy (SEM) and stabilized by glutaralde...

The ability to produce composite nanofibers from synthetic and natural polymers represents a significant advancement in development of composite materials with structural and material properties that will support biomedical applications such as tissue engineering, drug delivery and wound healing. In this research composite nanofiber membranes of magnesium oxide (MgO), poly (ε-caprolactone) (PCL...

The broader application of liposomes in regenerative medicine is hampered by their short half-life and inefficient retention at the site of application. These disadvantages could be significantly reduced by their combination with nanofibers. We produced 2 different nanofiber-liposome systems in the present study, that is, liposomes blended within nanofibers and core/shell nanofibers with embedd...