hearing loss (hl) is the most common communication disorder affecting about 1/1000 births worldwide caused by environmental or genetic factors. about 30-50% is attributed to genetic factors and till now more than 85 genes have been implicated in non-syndromic hl. in iran, hl is second to intellectual disability as the most common disability, affecting 1 of every 166 persons. about 15 years ago ...

represented by a block model that divides the orebody into a three-dimensional array of blocks. Each block consists of a cluster of similar characteristics such as rock type and ore grade, and has attributes such as tonnage of ore contained within the block and an expected economic value (Bley et al., 2010). For each block, the mine production scheduling problem consists of the decisions of (1)...

Background. Congenital heart block is characterized by blockage of electrical impulses from the atrioventricular node (AV node) to the ventricles. This blockage can be caused by ion channel impairment that is the result of genetic variation. This study aimed to investigate the possible causative variants in a Thai family with complete heart block by using whole exome sequencing. Methods. Genomi...

Abstract Phosphates, and especially potash, play an essential role in the increase crop yields. Potash is mined Germany underground mines using a conventional drill-and-blast technique. The most commercially valuable mineral contained potash potassium chloride that separated from aboveground processing plants. plants perform economically best if amount of output equal to specific value, so-call...

BACKGROUND Genome-wide association studies have made substantial progress in identifying common variants associated with human diseases. Despite such success, a large portion of heritability remains unexplained. Evolutionary theory and empirical studies suggest that rare mutations could play an important role in human diseases, which motivates comprehensive investigation of rare variants in seq...

BACKGROUND Local anesthetics (LA) work by blocking sodium conductance through voltage-gated sodium channels. Complete local anesthetic resistance is infrequent, and the cause is unknown. Genetic variation in sodium channels is a potential mechanism for local anesthetic resistance. A patient with a history of inadequate loss of sensation following LA administration underwent an ultrasound-guided...