Inflow of preformed ammonia in arterial blood, renal production of ammonia, outflow of ammonia in renal venous blood, and urinary excretion of ammonia were measured during the infusion of (15)NH(4)Cl into one renal artery of dogs with chronic metabolic acidosis. Our results show that the specific activity of ammonia measured in the urine and that calculated in the renal pool agree within 95%. P...

Approximately three fourths of the ammonia content of whole blood is contained in the red cells and one fourth in the plasma of normal subjects. As shown previously, the ammoniat concentration of erythrocytes is normally about three times that of plasma.' Significant differences from the normal distribution occur, however, in patients with anemia or elevated blood ammonia levels.! Elevations in...

The estimation of ammonia in the blood is a difficult matter not. only because ammonia is present in very minute quantities, but also because it is rapidly split off from some labile components of shed blood. The removal of the ammonia by means of an air current is subject to a source of error in as much as the amount of ammonia recovered may vary with the rapid&y of the aeration and the temper...

In 1919 Fosse (6) showed that urea is formed by the oxidation of solutions containing such amounts of glucose and ammonia as are present in the blood. Recently Hynd (9) found that “A 2 per cent solution of glucose containing approximately 60 mg. NH3 showed no optical change at room temperature, but after 24 hours at 50” the rotation fell from +0.87” to +0.29” . . . . Similar results were obtain...

Disturbance of ammonia metabolism is an important but not the only factor in the genesis of hepatic coma. In this review mechanisms controlling the concentration of ammonia in the blood other than disturbed liver function have been discussed. The key function of ammonia in the pyridine nucleotide cyde has been outlined and it is suggested that the function of this cycle in patients with liver d...

The estimation of ammonia in the blood is a difficult matter not. only because ammonia is present in very minute quantities, but also because it is rapidly split off from some labile components of shed blood. The removal of the ammonia by means of an air current is subject to a source of error in as much as the amount of ammonia recovered may vary with the rapid&y of the aeration and the temper...

The kidney consistently releases ammonia into the renal venous circulation of normal subjects and patients with compensated liver disease (1-4). Under conditions of normal acid-base balance, the quantity released usually approximates the amount of ammonia excreted into urine (3, 4). From determinations of arteriovenous ammonia differences across various organs, it has become apparent that the r...