objective(s) calcium-channel blockers have an important role in the treatment of several cardiovascular disorders. derivatives of 1, 4-dihydropyridine are one of the most potent calcium antagonists. in this study four novel ', 4-dihydropyridine calcium channel blockers were synthesized and their hypotensive properties were investigated in male rats. materials and methods four 1, 4-dihydrop...

background: esophagectomy is considered to be the main treatment for esophageal malignancies. among the different methods, transhiatal approach can cause less damage to patients and is widely used however, manipulation of esophagus result in heart rate and blood pressure variations. the aim of this study was to investigate changes in blood pressure and heart rhythm during transhiatal esophagect...

introduction: epinephrine-containing lidocaine is the most used anestheic drug in dentistry. the aim of this study was to investigate the hemodynamic changes following local infiltration of 2%lidocaine with 1:80,000 epinephrine in subjects undergoing orthognatic surgery under general anesthesia. methods: twenty five patients without any systemic disease participated. after general anesthesia, t...

effects of inhaled essential oils (eos) cannot be explained by pharmacological mechanisms alone. the study aimed to investigate the effects of pleasantness of and expectancies evoked by eos. a double-blind experiment with a within-subject design was carried out with the participation of 33 volunteering adults (15.2% male; mean age 37.7 ± 10.90 years). participants were exposed to three eos (...

background: hospitalization in the coronary care unit (ccu) is a concern for patients and their companions. different studies have presented conflicting results about the effect of visitors on physiological parameters of patients. the purpose of this study was to determine changes in physiological parameters (systolic and diastolic blood pressure and heart rate) due to presence of visitors at t...

background: new pressor protein (npp) is a human plasma enzyme structurally related to b–fragment of activated factor xіі (β-fxiia). the objective of the present study was to investigate the effects of npp and β-fxiia on systolic blood pressure and heart rate in bilateral nephrectomized rats.   methods: forty male wistar rats (250-300 g) were sham-operated or bilaterally nephrectomized under an...