BACKGROUND BMS-663068 is a prodrug of the small-molecule inhibitor BMS-626529, which inhibits human immunodeficiency virus type 1 (HIV-1) infection by binding to gp120 and interfering with the attachment of virus to CD4+ T-cells. METHODS Fifty HIV-1-infected subjects were randomized to 1 of 5 regimen groups (600 mg BMS-663068 plus 100 mg ritonavir every 12 hours [Q12H], 1200 mg BMS-663068 plu...

An acidic polysaccharide of Panax ginseng (APG), so called ginsan is known to have important immunomodulatory activities. It was recently reported that APG has radioprotective effects in mice but the detailed mechanism was not fully elucidated. This study examined the effects of APG on bone marrow cells (BMs). The phenotypical and functional changes in APG-treated BMs after gamma radiation were...

The HIV-1 envelope (Env) spike is a conformational machine that transitions between prefusion (closed, CD4- and CCR5-bound) and postfusion states to facilitate HIV-1 entry into cells. Although the prefusion closed conformation is a potential target for inhibition, development of small-molecule leads has been stymied by difficulties in obtaining structural information. Here, we report crystal st...

conclusions based on the results of the present study, patients with bms had sleep disorders, which should be considered in the clinical evaluation and treatment planning of these patients. results the mean age of the subjects in the bms and control groups were 49.9 ± 11 and 48.5 ± 8.3 years, respectively. the prevalence rates of sleep disorders in the bms and control groups were 78% and 38.7%,...

Building materials (BMs) are major contributors to indoor emission sources of volatile organic compounds (VOCs). In this study, 8 kinds of BMs (including conventional and green) for ceiling, cabinetry, and flooring commonly used indoors were tested in a 216 L chamber. Primary emissions of carbonyls (C1 to C8 aldehydes and ketones) at 48 h were 75e673 mg m 2 h 1 from conventional BMs, and 62 e15...

Burning mouth syndrome is characterized by both positive (burning pain, dysgeusia and dysesthesia) and negative (loss of taste and paraesthesia) sensory symptoms involving the lips and tongue, mainly the tip and anterior two-thirds. BMS patients report a persistently altered (metallic) taste or diminished taste sensations. Acidic foods such as tomatoes and orange juice cause considerable distre...

A practical Bridge Management System has been developed by the author, which is referred to as the Japanese Bridge Management System (J-BMS) for existing concrete bridges. This paper introduces a newly developed bridge management system for the prestressed concrete (PC) bridges (J-BMS PC version) which is integrated with the PC bridge rating expert system (PC-BREX). The proposed system is able ...

This paper describes a method of performance evaluation and remaining life prediction for an aged reinforced concrete (RC) T-girder bridge by J-BMS RC version via close visual inspection data, and also verifies the assessment results obtained as outputs from the Bridge Rating Expert System (RC-BREX) which is a subsystem of the J-BMS, to evaluate the effectiveness of the system. The Bridge Manag...

Gemcitabine has limited clinical benefits in pancreatic ductal adenocarcinoma (PDAC). Insulin-like growth factor (IGF) signaling proteins are frequently overexpressed in PDAC. The therapeutic potential of BMS-754807, a small-molecule inhibitor of IGF-type 1 receptor (IGF-1R) and insulin receptor (IR), and gemcitabine was evaluated in experimental PDAC. Cell proliferation and protein expression ...