currently autografts are gold standards for craniomaxillofacial bone regeneration. but autografts have some limitations. bone tissue engineering has been introduced to overcome these limitations. it consist three components: stem cells, growth factor, and scaffold. scaffold provides an environment for bone growth and simplifies cell adhesion, differentiation and proliferation. in this review, a...

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introduction: transplantation of bone marrow stromal cells (bmscs) or schwann cells (scs) can increase axonal regeneration in peripheral nerve injuries. based on our previous investigations, the goal of the present work was to examine the individual and synergistic effects of the two different cell types in sciatic nerve injury . we pursued to evaluate the effects of bmscs and scs co-transplant...

statement of problem: the guided bone regeneration (gbr) technique does not always produce consistent results. bone filling within the space provided by the membrane can be incomplete. purpose: the aim of this study was to evaluate the effect of a collagen membrane (bio-gide) in combination with or without deproteinezed bovine bone mineral (bio-oss) on the healing of calvarial defects in rabbit...

background and objective: the concept of immediate occlusal loading with dental implants offers several advantages. in this research, the effect of type of restoration on osseointegration rate of dental implants was histologically evaluated. materials and methods: three months prior to implantation, the lower premolar teeth of 15 dogs were extracted. then, 3 to 4 maestro™ implants were placed i...

the biological interaction between the jaw bones and dental implant is fundamental for the long-term success of dental implant placement. nevertheless, the insufficient bone volume remains a major clinical problem, especially in case of immediate dental implant. using a canine model, the present study proves the regenerative potential of adipose- derived stem cells (adscs) to repair peri-implan...

background: the aim of this research was to evaluate the effect of adipose derived stem cells on bone repair in through and through mandibular bone defects of canine. materials and methods: in this prospective comparative study, adipose-derived stem cells were isolated from subcutaneous fat of lateral thoracic area of 4 dogs. the isolated cells were cultured and expanded through 3 passages. the...

both anorganic bovine bone (abb) and β-tricalcium phosphate (β-tcp) are used in clinical practice as bone substitute materials, but there is limited data comparing these two materials in standardized defects. the aim of this study was to histologically evaluate the effectiveness of abb and β-tcp in the healing of experimentally induced bone defects.eighteen bone defects were created on the calv...