background mandibular continuity defects occur after tumor resection, maxillofacial injury, or osteomyelitis. despite the current availability of a plethora of treatment modalities, bone substitutes, and various clinical adjuncts, an exact reconstructive recapitulation of large bony defects continues to be beyond reach. in this clinical pilot study, we report a novel method for reconstruction o...

objective: to date, several scaffolds have been fabricated for application in bone tissue repair. however, there remains a need for synthesis of scaffolds with better mechanical properties, which can be applied to defects in weight-bearing bones. we constructed a composite ceramic bioscaffold of hydroxyapatite-alumina and silicon carbide (ha-al2o3- sic) to take advantage of the mechanical prope...

background: spinal cord has a limited capacity to repair therefore, medical interventions are necessary for treatment of injuries. transplantation of schwann cells has shown a great promising result for spinal cord injury (sci). however, harvesting schwann cell has been limited due to donor morbidity and limited expansion capacity. furthermore, accessible sources such as bone marrow stem cells ...

background: bone tissue engineering requires materials that are biocompatible, mechanically suited for bone function, integrated with the host skeleton, and support osteoinduction of the implanted cells for new bone formation. the aim of this study was to compare the osteogenic potential of xenograft with hydroxyapatite/β- tricalcium phosphate (ha/β-tcp) scaffold. methods: new zealand rabbits (...

Background Mandibular continuity defects occur after tumor resection, maxillofacial injury, or osteomyelitis. Despite the current availability of a plethora of treatment modalities, bone substitutes, and various clinical adjuncts, an exact reconstructive recapitulation of large bony defects continues to be beyond reach. In this clinical pilot study, we report a novel method for reconstruction ...

Background: Tissue engineering using Stem cell from Human Exfoliated Deciduous Teeth (SHED) and a natural biomaterials biomaterial scaffold has become a promising therapy for the alveolar bone defect. The aim of this study was to analyze the Osteoprotegerin (OPG) and Receptor Activator of NF-Κb ligand (RANKL) expression after the application of Hydroxyapatite scaffold and SHED.Methods: A labora...

Background: Bone tissue engineering requires materials that are biocompatible, mechanically suited for bone function, integrated with the host skeleton, and support osteoinduction of the implanted cells for new bone formation. The aim of this study was to compare the osteogenic potential of xenograft with hydroxyapatite/β- tricalcium phosphate (HA/β-TCP) scaffold. Methods: New Zealand rabbits (...

Objective(s): Scaffolds are considered as biological substitutes in bone defects which improve and accelerate the healing process of surrounding tissue. In recent years a major challenge in biomaterials is to produce porous materials with properties similar to bone tissue. In this study, the natural bioactive hydroxyapatite scaffolds with nano Diopside /Forstrite coating was successfully synthe...

Objective(s): Bacterial cellulose (BC) has applications in medical science, it is easily synthesized, economic and purer compared to plant cellulose. The present study aimed to evaluate BC, a biocompatible natural polymer, as a scaffold for the bone marrow mesenchymal stem cells (BMSCs) loaded with fisetin, a phytoestrogen.Materials and Methods: BC hydrogel scaffold was prepared from Gluconacet...