The chemistry of organometallic compounds with bulky ligands such as (Me3Si)3C(Tsi) or (Me2PhSI)3C(Tpsi) attached to a variety of metal centres is reviewed. The compounds Tsi2M (M = Zn, Cd, Hg) and the rare two co-ordinate TsiMn show exceptional thermal and hydrolytic stability. The corresponding alkylmetal halides form ring or cage structures. In a range of new boron compounds the structures o...

Radiation therapy is the therapeutic modality in which high energy radiations are used to kill tumor cells [1]. Conventional radiation therapy is a whole body radiation process resulting in numerous side effects, highlighting the need to identify alternative targeted therapy [1]. BNCT is a targeted therapy in which cancer cells accumulate boron and are subsequently bombarded with neutrons [2]. ...

The push-pull character of a series of donor-bithienyl-acceptor compounds has been tuned by adopting triphenylamine or 1,1,7,7-tetramethyljulolidine as a donor and B(2,6-Me2 -4-RC6 H2)2 (R=Me, C6 F5 or 3,5-(CF3)2 C6 H3) or B[2,4,6-(CF3 )3 C6 H2]2 as an acceptor. Ir-catalyzed C-H borylation was utilized in the derivatization of the boryl acceptors and the tetramethyljulolidine donor. The donor a...

An efficient deborylthiolation of aryl- and alkenylborons with thiosulfonates has been achieved under mild conditions using a copper catalyst. All steps of the experimental process were free from unpleasant odors. The mild reaction conditions as well as ready availability of boron compounds and thiosulfonates enabled easy access to an array of sulfides, including those bearing sensitive functio...

Cationic and zwitterionic boryl bromide species and a borenium-boryl bromide cation have been synthesised which represent new N-donor stabilised cationic boron compounds with β-diketiminate ligands. The unexpected borenium-boryl bromide results from a head-to-tail dimerisation of the corresponding zwitterionic boryl bromide accompanied by proton migration. The electronic nature of these new spe...

A series of mononuclear boron halides of the type LBX(2) [LH = N-phenyl-3,5-di-tert-butylsalicylaldimine, X = Cl (2), Br (3)] and LBX [LH2 = N-(2-hydroxyphenyl)-3,5-di-tert-butylsalicylaldimine, X = Cl (7), Br (8); LH2 = N-(2-hydroxyethyl)-3,5-di-tert-butylsalicylaldimine, X = Cl (9), Br (10); and LH2 = N-(3-hydroxypropyl)-3,5-di-tert-butylsalicylaldimine, X = Cl (11), Br (12)] were synthesized...

Despite the improvements in cancer therapy during the past years, high-grade gliomas and many other types of cancer are still extremely resistant to current forms of therapy. Boron neutron capture therapy (BNCT) provides a promising way to destroy cancer cells without damaging healthy tissue. However, BNCT in practice is still limited due to the lack of boron-containing compounds that selective...

Boronic acids are versatile reagents for the chemical synthesis of organic molecules. They and other boron-containing compounds can be detected readily by the interruption of the excited-state intramolecular proton transfer (ESIPT) of 10-hydroxybenzo[h]quinolone. This method is highly sensitive and selective, and useful for monitoring synthetic reactions and detecting boron-containing compounds...

the six elements commonly known as metalloids are boron, silicon, germanium, arsenic, antimony, and tellurium. metalloid containing compounds have been used as antiprotozoal drugs. boron-based drugs, the benzoxaboroles have been exploited as potential treatments for neglected tropical diseases. arsenic has been used as a medicinal agent and arsphenamine was the main drug used to treat syphilis....