The Siah proteins, mammalian homologues of the Drosophila Sina protein, function as E3 ubiquitin ligase enzymes and target a wide range of cellular proteins for degradation. Here, I investigate the in vivo function of the fly protein, Sina-Homologue (SinaH), which is highly similar to Sina. Flies that completely lack SinaH are viable and in combination with a mutation in the gene, Ebi, show an ...

We show that Tramtrack (TTK88) expression represses neuronal fate determination in the developing Drosophila eye. Phyllopod (PHYL) acts to antagonize this repression by a mechanism that requires Seven In Absentia (SINA) and is associated with decreased TTK88 protein levels, but not reduced ttk88 gene transcription or mRNA stability. We present evidence that SINA, PHYL, and TTK88 physically inte...

This paper examines the impact of the introduction of Sina Weibo, the most popular microblog in China, on the quality of drugs on the market. Using a unique data set on drug quality and Sina Weibo use, I explore the staggered diffusion of Sina Weibo across prefectures. I find that the number of bad drugs is decreasing in Sina Weibo use: if the Sina Weibo use is doubled, the number of bad drugs ...

Sina Weibo, which was launched in 2009, is the most popular Chinese micro-blogging service. It has been reported that Sina Weibo has more than 400 million registered users by the end of the third quarter in 2012. Sina Weibo and Twitter have a lot in common, however, in terms of the following preference, Sina Weibo users, most of whom are Chinese, behave differently compared with those of Twitte...

the purpose of this research is to investigate the effects of intelligence beliefs and achievement motivation on learning strategies and academic performance of agricultural students. this research was descriptive - correlation with data collected using questionnaire. the statistical population included students in colleges of agriculture at universities of tehran, bouali sina, ilam, shahid bah...

Sina Weibo, China’s most popular microblogging platform, is currently used by over 500M users and is considered to be a proxy of Chinese social life. In this study, we contrast the discussions occurring on Sina Weibo and on Chinese language Twitter in order to observe two different strands of Chinese culture: people within China who use Sina Weibo with its government imposed restrictions and th...

The transcription repressor Tramtrack (TTK) is found in cone cells but not photoreceptor cells of the Drosophila eye. We show that down-regulation of TTK expression occurs in photoreceptor cells and is required for their fate determination. Down-regulation requires the presence of Phyllopod (PHYL), which is induced by the RAS pathway, and Seven In Absentia (SINA). Loss of either gene causes acc...

BACKGROUND Neuronavigation is an established technology in neurosurgery. In parts of the world and certain circumstances in which neuronavigation is not easily available or affordable, alternative techniques may be considered. OBJECTIVE An app to assist scalp localization of superficial supratentorial lesions has been introduced, and its accuracy has been compared with established neuronaviga...

There has been a tremendous rise in the growth of online social networks all over the world in recent years. This has facilitated users to generate a large amount of real-time content at an incessant rate, all competing with each other to attract enough attention and become trends. While Western online social networks such as Twitter have been well studied, characteristics of the popular Chines...