Complexes with purely pyridine-based macrocycles are rarely studied in photo(electro)catalysis. We synthesized and investigated macrocycles, in which two 2,2'-bipyridine (bpy) units are linked twice by two cyano-methylene groups, to yield the basic tetradentate, bipyridine based ligand framework (pyr). The protons in the bridges were substituted to obtain derivatives with one (pyr-alk) or two (...

We report the detection of an unstable intermediate generated during Br oxidation to Br3 in nitrobenzene by scanning electrochemical microscopy (SECM), and we attempt to simulate the collection of the intermediate using a proposed mechanism of Br oxidation to Br3 . At a distance of 3.5 mm between the tip and the substrate electrode in the SECM experiment, we observed two waves as we measured th...

The bromination of a series of cyclohexenyl substituted secondary amines 1a-i has been investigated using Br2, PHT and NBS. In the case of Br2 and NBS the secondary amines preferentially undergo N-bromination. In contrast, PHT cleanly affords the products of alkene dibromination. In the case ofBr2 the N-bromo species then give the products of alkene dibromination, albeit less efficiently. On su...

PURPOSE The pro-inflammatory effects of kinins are mediated by two bradykinin receptors: BR1 and BR2. The aim of this study was to evaluate the expression profile of kinin receptor genes by an estimation of mRNA levels in human nasal polyps (NP) and normal mucosa (NM). MATERIAL AND METHODS BR1 and BR2-dependent genes differentially transcribed in NP were investigated using oligonucleotide mic...

The intimate link between location of fat accumulation and metabolic disease risk and depot-specific differences is well established, but how these differences between depots are regulated at the molecular level remains largely unclear. Here we show that TRIP-Br2 mediates endoplasmic reticulum (ER) stress-induced inflammatory responses in visceral fat. Using in vitro, ex vivo and in vivo approa...

The effect of relatively low concentrations Br2(g) in the Cl2(g) feedstock for phosgene synthesis catalysis via reaction CO(g) and over activated carbon (Donau Supersorbon K40) is explored. Under stated conditions absence a catalyst, BrCl(g) forms from Br2(g). Phosgene catalyst at 323 K investigated Br2(g):Cl2(g) molar flow ratios range 0–1.52% (0–15,190 ppm) shows enhanced rates production. Ma...

Transition metals offer many possibilities in developing potent chemotherapeutic agents. They are endowed with a variety of oxidation states, allowing for the selection of their coordination numbers and geometries via the choice of proper ligands, leading to the tuning of their final biological properties. We report here on the synthesis, physico-chemical characterization, and solution behavior...