Chronic consumption of a diet enriched with nutritional precursors of phospholipids, including uridine and the polyunsaturated fatty acids, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), was shown previously to enhance levels of brain phospholipids and synaptic proteins in rodents. Vitamin C, vitamin E, and selenium may directly affect the breakdown or synthesis of membrane phospho...

Despite numerous defenses, the brain is vulnerable to oxidative stress resulting from ischemia/reperfusion. Excitotoxic stimulation of superoxide and nitric oxide production leads to formation of highly reactive products, including peroxynitrite and hydroxyl radical, which are capable of damaging lipids, proteins and DNA. Use of transgenic mutants and selective pharmacological antioxidants has ...

Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a polyphenolic phytoalexin that exerts cardioprotective, neuroprotective, and antioxidant effects. Recently it has been shown that obesity is associated with an increase in cerebral oxidative stress levels, which may enhance neurodegeneration. The present study evaluates the neuroprotective action of resveratrol in brain of obese (ob/ob) mice. R...

Oxidative stress is the main cause of impairment of learning and memory. It may occur due to suppression of various brain functions. Antioxidants are therefore very helpful in maintaining the brain functions and improving memory. They are very useful in enhancement of spatial memory also. Various preclinical and clinical studies have been performed on their role in memory enhancement. It has be...

Monosodium glutamate (MSG) was administrated subcutaneously to wistar rats for 60 days and circadian rhythms of thiobarbituric acid reactive substances (TBARS) and antioxidants such as superoxide dismutase (SOD), reduced glutathione (GSH), catalase, glutathione peroxidase (GPX) and Vitamin-E were studied. Advanced acrophase of TBARS and delayed acrophase of antioxidants were found in experiment...

Alzheimer’s disease (AD) is characterized by progressive loss of memory and cognition. Our laboratory and many others have shown that the AD brain is under extensive oxidative stress. Numerous therapeutic approaches to AD therapy have been hypothesized. Among these are exogenous antioxidants. We suggest that the body’s own endogenous antioxidant systems should be mobilized against the oxidative...

Antioxidant activities of W and E extracts obtained from dried boxthorn (Lycium chinensis) fruit were measured based on DPPH radical scavenging and reducing powers, and their relationships with total phenolics, flavonoid content, and antioxidant activity were investigated. A linear correlation among antioxidant activity, total phenolics, and flavonoid content was observed in concentration-depen...