The aim of the present study was to determine mRNA expression profiles TRAIL-mediated cell death related genes hypoxia-tolerant rodent Nannospalax nehringi under hypoxia. nucleotide and amino acid sequences these were identified. Captured randomly divided into normoxia hypoxia groups. group exposed a 7% O2 + 93% N2 gas mixture for 52 h, while animals in housed normoxic conditions. Total RNAs is...

Background: Medial prefrontal cortex (mPFC) is considered to be involved in human cognition mPFCin terms of learning and memory. Hypoxia one the crucial factors causing secondary damage incerebral hemorrhage traumatic brain injury. However, underlying mechanisms possibletherapeutic approach prevent neuronal has not been attempted yet. Therefore, present studyaimed investigate role Tualang honey...

Hypoxemia is a major comorbid factor for permanent brain damage in several metabolic encephalopathies. To determine whether hypoxia impairs brain adaptation to hyponatremia, worsening brain edema, we performed in vitro and in vivo studies in cats and rats with hyponatremia plus either ischemic or hypoxic hypoxia. Mortality with hypoxic hypoxia was 0%; with hyponatremia, 22%; and with hyponatrem...

Introduction: Recent studies suggest that dietary virgin olive oil (VOO) reduces hypoxia-re oxygenation injury in rat brain. We have attempted to determine the effect of dietary virgin olive oil on brain lipidomics and its relationship with brain edema in a rat stroke model. Methods: Five groups, each consisting of 6 male Wistar rats, were studied. The first and second groups (control and s...

Neonatal hypoxia leads to clinically significant fatty liver, presumably due to disturbances in lipid metabolism. To fully evaluate lipid metabolism, the present study analyzed the complete lipid profile of the brain, liver, and ingested stomach contents of 7-day-old rats exposed to hypoxia from birth. Hypoxia had negligible direct effects on lipid metabolism in the brain. Conversely, hypoxia e...

PURPOSE Hypoxia is one of the important factors in formation of reactive oxygen species (ROS). Ghrelin is a peptide hormone that reduces oxidative stress. However, antioxidant effect of ghrelin on blood and brain in normobaric hypoxia condition has not yet been investigated. METHODS thirty-two animals were randomly divided into four (n=8) experimental groups: Control (C), ghrelin (Gh), hypoxi...

The absolute reliance of the mammalian brain on oxygen to generate ATP renders it acutely vulnerable hypoxia, whether at high altitude or in clinical settings anemia pulmonary disease. Hypoxia is pivotal pathogeneses myriad neurological disorders, including Alzheimer’s, Parkinson’s and other age-related neurodegenerative diseases. Conversely, reduced environmental oxygen, e.g. sojourns residing...

Changes in brain vascularity in adult rats during adaptation to chronic normobaric hypoxia with or without elevated CO(2) were morphometrically investigated. Immunohistochemistry with anti-rat endothelial cell antigen (RECA-1) antibody was carried out for the vascular analysis. After the rats were subjected to hypoxia for 2 to 8 weeks (wks)(10 percent O(2) in N(2)), the total area of blood vess...

Hypoxia increases cerebral blood flow (CBF), but it is unknown whether this increase is uniform across all brain regions. We used H(2)(15)O positron emission tomography imaging to measure absolute blood flow in 50 regions of interest across the human brain (n = 5) during normoxia and moderate hypoxia. Pco(2) was kept constant ( approximately 44 Torr) throughout the study to avoid decreases in C...