ischemic brain injury involves a complex sequence of excitetoxic and oxidative events. metformin is proposed as one of the potential candidates for returning the body to its basic homeostasis in ischemic situations. metformin can either protect or damage cells by activating amp-activated protein kinase (ampk) and its downstream factors so, it has a dual role in the cerebral ischemia context, bu...

results in all groups ischemic changes were apparently observed in hippocampus ca1 neurons. in two-vessel occlusion model, after 3 and 24 hours of reperfusions, ischemic cells accounted for 14.9% and 23.2%, respectively. in four-vessel occlusion model, after 3 and 24 hours of reperfusions, ischemic cells accounted for 7.6% and 44.9% (p < 0.0001), respectively. background an appropriate animal m...

Introduction: Cerebral ischemia and reperfusion causes physiological and biochemical changes in the neuronal cells that will eventually lead to cell damage. Evidence indicates that exercise reduces the ischemia and reperfusion-induced brain damages in animal models of stroke. In the present study, the effect of exercise preconditioning on brain edema and neurological movement disorders followin...

Insults to the brain that are sub-threshold for damage activate endogenous protective pathways, which can temporarily protect the brain against a subsequent harmful episode. This mechanism has been named as tolerance and its protective effects have been shown in experimental models of ischemia and epilepsy. The preconditioning-stimulus can be a short period of ischemia or mild seizures induced ...

Ischemic tolerance describes the adaptive biological response of cells and organs that is initiated by preconditioning (i.e., exposure to stressor of mild severity) and the associated period during which their resistance to ischemia is markedly increased. This topic is attracting much attention because preconditioning-induced ischemic tolerance is an effective experimental probe to understand h...

Preconditioning the rat brain with spreading depression for 48 h induces potent ischemic tolerance (infarct tolerance) after an interval of 12-15 days, consequently reducing the infarcted lesion size in the acute phase following focal cerebral ischemia. However, persistence of the morphological and functional neuroprotection has not yet been proven. We tested whether tolerance-derived neuroprot...

background & objectives: ischemic stroke is the third leading cause of death and disability in most of the human societies. there is no effective treatment due to complexity of the pathophysiological mechanisms. today, more researches are designed to introduce involving factors and new treatment strategies in brain ischemia. the objective of this study is to introduce an experimental model of t...

results the i/r group showed a significant increase in pycnotic (dying) neurons and pretreatment with wc at doses of 500 mg/kg and 1000 mg/kg significantly reduced pycnotic and tunel positive neurons, in a dose dependent manner in ischemic brain cortex. conclusions our findings indicated that wc has neuroprotective effects and is able to reduce histopathological alterations and apoptosis in bra...

objective: the results of the previous studies on the correlation between plasma levels of homocysteine (hcy) and ischemic stroke have been controversial. the aim of the present study is to investigate this correlation meticulously observing risk factors for the ischemic stroke as well as factors affecting the plasma levels of hcy. method: a case-control study was conducted between 2005-2006 wi...