a neurological disorder is any disorder of the nervous system is usually due to cell loss. the ultimate goal of cns therapy is to replace lost cells and tissue. there is no neuroprotective, pharmacological and effective treatment available that restores the injury-induced loss of function. recent studies suggest that identification of adult neural stem/progenitor cells indwelling in the neuroge...

Traumatic brain injury (TBI) is described by a disruption in the normal function of the brain due to an injury following a trauma, which can potentially cause severe physical, cognitive, and emotional impairment. The use of human stem cells and self-assembling peptide scaffolds suggest huge potential for application in the treatment of TBI. In the present study, we surveyed the beneficial effec...

background: brainstem hemorrhage was first described by cheyne in 1812 in a pathological study of patients presenting with lethargy and coma. in 1877 bode reviewed the findings of 67 patients reported in the literature (1). in the united states, the incidence of closed head injury is estimated to be approximately 200 cases per 100,000 persons per year. the financial burden of head injuries in t...

Background: Brainstem hemorrhage was first described by Cheyne in 1812 in a pathological study of patients presenting with lethargy and coma. In 1877 Bode reviewed the findings of 67 patients reported in the literature (1). In the United States, the incidence of closed head injury is estimated to be approximately 200 cases per 100,000 persons per year. The financial burden of head injuries in...

conclusions according to our results, silymarin injection caused significant differentiation of mscs to neurons and neuroglia that could be a promising approach for treating a variety of brain injuries. results expression of cd29 and cd90 markers that are characteristic of bmmscs were confirmed by flow cytometry experiments. the data demonstrated that proliferation and number of progenitor cell...

Traumatic brain injury (TBI) is physical damage to the brain structure which has a high global rate of mortality and morbidity. TBI can cause intense inflammatory response due to accumulation of leukocytes in cerebral matrix and activation of microglia. Microglia can differentiate into M1 macrophages or M2 macrophages following the changes in biochemical properties of brain tissue. M1 sub type ...

one of the main problems following road accidents is brain injury after which death and disability in the most active population occurs. considering the fact that there is no definite clinical treatment for repair of damaged brain tissue, the present study examined the effects of autologous adult neural stem/progenitor cells (ns/pcs) seeded in a nanoscaffold named puramatrix in acute brain inju...

traumatic brain injury (tbi) is physical damage to the brain structure which has a high global rate of mortality and morbidity. tbi can cause intense inflammatory response due to accumulation of leukocytes in cerebral matrix and activation of microglia. microglia can differentiate into m1 macrophages or m2 macrophages following the changes in biochemical properties of brain tissue. m1 sub type ...

neuroinflamation occurring after traumatic brain injury (tbi) is a complex phenomenon comprising distinct cellular and molecular events involving the injured cerebral tissue. mechanical injury to adult rat brain elucidated the accumulation in the affected area of trophic activity. in the tissue adjacent to the injury, trophic titers began to rise after the lesion. this study aimed to determine ...

I read with great interest the article by Hilario et al. The authors retrospectively analyzed the MR imaging data from the first 30 days after injury in 108 patients with severe head trauma and found that the presence of posterior and bilateral brain stem injuries were poor prognostic signs. Although they analyzed the location of the brain stem lesions, they did not analyze the volume or depth ...