Starving tumors eat metabolic enzyme Xia et al. describe a way to force cancer cells to destroy a key metabolic enzyme they need to survive. Autophagy helps cancer cells survive the stressful environment inside a tumor. However, blocking the process doesn’t kill cancer cells, so researchers have been looking for a way to make cells vulnerable to autophagy shutdown. Xia et al. used an ovarian ca...

The branching of dendrites and axons is a key determinant of neural circuit formation. In this issue of Neuron, Kawabe et al. demonstrate that the ubiquitin ligase Nedd4 promotes the branching of developing dendrites by targeting the small G protein Rap2. In a complementary study, Drinjakovic et al. show that Nedd4 promotes the branching of developing axons by ubiquitinating a different target,...