During the development of the Drosophila adult peripheral nervous system (PNS), inhibitory cell-cell interactions mediated by the Notch receptor are essential for proper specification of sensory organ cell fates. We have reported previously (M. W. Leviten, E. C. Lai and J. W. Posakony (1997) Development 124, 4039-4051) that the 3' untranslated regions (UTRs) of many genes involved in Notch sign...

We investigated the effect of brown ring disease (BRD) development and algal diet on energy reserves and activity of enzymes related to energy metabolism, antioxidant system and immunity in Manila clam, Ruditapes philippinarum. We found that algal diet did not impact the metabolic response of clams exposed to Vibrio tapetis. At two days post-injection (dpi), activities of superoxide dismutase a...

Data on associations between weather conditions and bovine respiratory disease (BRD) morbidity in autumn-placed feedlot cattle are sparse. The goal of our study was to quantify how different weather variables during corresponding lag periods (considering up to 7 d before the day of disease measure) were associated with daily BRD incidence during the first 45 d of the feeding period based on a p...

We have isolated a novel class of gain-of-function mutations at the Bearded (Brd) locus which specifically affect the development of adult sensory organs in Drosophila. These Brd alleles cause bristle multiplication and bristle loss phenotypes resembling those described for the neurogenic genes Notch (N) and Delta (Dl). We have found that supernumerary sensory organ precursor (SOP) cells develo...

The primary objective of this study was to estimate variance components and heritability of bovine respiratory disease (BRD) incidence in beef calves before weaning and during the finishing phase. The second objective was to investigate the impact of BRD incidence and treatment frequency on performance and carcass traits. Bovine respiratory disease is the biggest and most costly health challeng...

Bovine respiratory disease (BRD) is the most common economically important disease affecting cattle. For developing accurate diagnostics that can predict disease susceptibility/resistance and stratification, it is necessary to identify the molecular mechanisms that underlie BRD. To study the complex interactions among the bovine host and the multitude of viral and bacterial pathogens, as well a...

This issue of Animal Health Research Reviews contains the Proceedings of the Bovine Respiratory Disease Symposium 2014: ‘New Approaches to Bovine Respiratory Disease Prevention, Management and Diagnosis’, which was held on July 30 and 31, 2014 in Denver, Colorado, USA. Bovine respiratory disease (BRD) remains a leading cause of illness, death and decreased productivity for cattle in North Ameri...

A study was conducted to evaluate the diagnostic and prognostic value of thoracic ultrasonography (TUS) in feedlot calves with clinical signs attributable to bovine respiratory disease (BRD). Twenty-nine BRD cases and 15 asymptomatic controls were evaluated using systematic TUS on the day of initial pull (day 0), and days 3, 6, 9, and 15. Four-second ultrasound loops were saved at 46 locations ...

This paper describes an action research study which focussed on requirements capture for a subscription-based business-to-consumer (B2C) electronic commerce (EC) system. The study used a recently developed approach to requirements elicitation, the Business Rules Diagram (BRD) Method. The BRD method was adapted somewhat during the study and was found to be helpful in addressing difficulties of r...

The objective of this study was to characterize genetic and environmental factors influencing bovine respiratory disease (BRD) in beef cattle. Records from nine purebred and three composite breeds and a variety of F1 and three-way crosses, including the progeny of 12 additional different sire breeds produced over a 20-yr period (1983 to 2002), were evaluated for breed and heterozygosity effects...