objectives colloidal drug delivery system, solid lipid nanoparticles (slns), helps to increase the solubility of the drug and its oral bioavailability. methods tamoxifen (tam) as a nonsteroidalantiestrogen drug was formulated in sln and an in vitro study was conducted to determine the cytotoxicity effect of tam-loaded slns on human breast cancer cell lines mcf-7 (estrogen receptor-positive) and...

conclusions this study on a limited number of patients treated with adjutant anthracyclins-based regimens, revealed that her2/neu is not a unique strong predictor for outcome, thus according to combination of her2/neu status and other clinical factors, it is necessary to distinguish patients at high risk of recurrence. results her2/neu amplification was identified in 19 (38%) of 50 patients. no...

conclusion in breast cancer after nac, the lesion t2 relaxation time was reduced in the responders, and this finding is potentially useful to assess the response to nac. results in 26 cases with nac, the mean lesion t2 relaxation time before nac was 81.34 ± 13.68 ms, compared with 64.50 ± 8.71 ms after nac. significant differences in the lesion t2 relaxation times existed between the pre- and p...

conclusion investigative assessment of breast us by residents is inadvisable. we recommend continued professional resident training to improve the degree of agreement and performance. results for the faculty members, fair-to-good agreement was obtained in all descriptors and final assessment, while for residents, poor-to-moderate agreement was obtained. the areas under the roc curves were 0.78 ...

conclusions although in our study washout pattern was the most powerful indicator for malignant pathology in non mass like enhancing lesions, more studies with larger sample size needs in this regard. background several studies on the diagnostic efficacy of mri has not real consensus for the accuracy of mri characteristics in non mass like breast lesions, and the number of malignant lesions in ...

conclusion st-vab and mgl-eb are reliable biopsy methods for microcalcifications. in proper indications, breast microcalcifications could be obtained by each method without missing diagnosis of breast cancer. objectives to evaluate the outcome of st-vab and mammography-guided localization and excisional biopsy (mgl-eb) for microcalcifications. patients and methods two radiologists retrospective...

The association of granuloma annulare and some neoplasms is controversial. However, there is an increase in the number of case reports and relevant studies supporting the conceptof granuloma annulare being associated with certain types of hematologic neoplasms and solid tumors.Herein, we describe a 54-year-old woman with a 20-month history of generalized annular lesions that did not respond to ...

mammary sarcomas are a heterogeneous group of malignant neoplasms that arise from the mammary stroma. primary sarcomas of the breast are extremely rare and comprise less than 0.1% of all malignant tumors of the breast. we present the case of a 56-year-old female diagnosed as stromal sarcoma, not otherwise specified - a very rare entity.

background and objectives: breast cancer is the most common malignancy and is the second leading cause of mortality due to cancer in women. one of the important psychological factors in these patients is death anxiety. given the role of religious orientation to this psychological factor, this study was conducted to investigate the relationship between religious orientation and death anxiety in ...

studies on biomedical applications of nanoparticles are growing with a rapid pace. in medicine, nanoparticles may be the solution for multi-drug-resistance which is still a major drawback in chemotherapy of cancer. in the present study, we investigated the potential cytotoxic effect of silver nanoparticles (ag nps) and silver ions (ag+) in both parent and tamoxifen-resistant t47d cells in prese...