Background: Previous studies have suggested that BRCA1 dysregulation has been shown to have a role in triple-negative phenotypic manifestation. However, differences of BRCA1 expression, as a tumor suppressor gene, have rarely been investigated between luminal and triple-negative breast tumors. Therefore, the present study attempted to compare the BRCA1 expression in triple-negative with lu...

objective: breast cancer is the most common cancer in iranian women. breast tumors are classified based on the estrogen receptor alpha (erα) expression status into er negative and er positive tumors. er negative tumors tend to have worse prognosis and less likely to respond to endocrine therapy. aberrant methylation of gene promoter is one of the mechanisms for gene silencing in breast tumors. ...

Phyllodes tumors are biphasic fibroepithelial neoplasms of the breast. While the surgical management of these relatively uncommon tumors has been addressed in the literature, few reports have commented on the surgical approach to tumors greater than ten centimetres in diameter – the giant phyllodes tumor. We report a case of giant breast tumors and discuss the techniques utilized for pre-...

background: ultrasound propagation velocity was measured experimentally in normal, fibroadenoma and ductal carcinoma breast tissues, in order to distinguish normal breast tissue from tumors. materials and methods: in quantitative measurements of ultrasound velocity, 403 breast tissue images were selected, comprising 130 normal breast tissue, 130 fibroadenoma, and 143 ductal carcinoma tumors. th...

Background & Aims: Nucleostemin is one of the stem cell enriched proteins which encodes a novel nucleolar GTP-binding protein found at high levels in the adult and embryonic stem (ES) cells but not in terminally differentiated cells. It is also expressed in tumor cell lines as well as in the several types of human cancers. Due to the increasing rate of breast cancer in recent years, in the pres...

Cytomegalovirus (CMV) is a widespread pathogen that is found in milk, saliva, urine, cervical secretions, and semen fluid. It is supposed that CMV is a risk factor for breast cancer. The aim of this study was to determine the frequency of CMV among benign and malignant breast tumors. Paraffin embedded breast carcinoma (n=24) and fibroadenoma (n=24) samples were collected from Toos and Firoozgar...

phyllodes tumors account for less than 1% of breast tumors in women. giant phyllodes tumors are larger than 10 cm in diameter. a 40-year-old lady presented with a left breast lump that was present for two years. she underwent a simple mastectomy. the tumor was 30×26×21 cm in size, weighed 15 kg and had a density of 0.915 gr/cm3. we believe this patient had the third largest breast phyllodes tum...

objective: estrogen receptor alpha protein status is determined by routine immunohistochemistry analysis in all malignant breast tumors. this assay has its limitations. rna based techniques are potential complements for immunohistochemistry but it must be noticed that gene silencing may occur at different levels from rna to protein. the aim of this study was the comparison of the results from t...

this study aimed to investigate the frequency of varicella zoster virus (vzv) in benign and malignant breast tumors. a total of 24 carcinomas and 24 fibroadenomas paraffin embedded tumoral tissue samples were obtained from the pathology sections of toos and firoozgar hospitals in tehran, iran. all samples were collected from patients from june 2011 to february 2012. dna was extracted from all s...