Growing evidence suggests that on-pathway amyloid-β (Aβ) oligomers are primary neurotoxic species and have a direct correlation with the onset of Alzheimer's disease (AD). One promising therapeutic strategy to block AD progression is to reduce the levels of these neurotoxic Aβ species using small molecules. While several compounds have been shown to modulate Aβ aggregation, compounds with such ...

A viable vascular endothelial layer prevents vasomotor dysfunction, thrombosis, inflammation, and intimal hyperplasia. Injury to the endothelium occurs during harvest and "back table" preparation of human saphenous vein prior to implantation as an arterial bypass conduit. A subfailure overstretch model of rat aorta was used to show that subfailure stretch injury of vascular tissue leads to impa...

The Piedmont enjoys a highly regarded reputation for its historic sites and its world-class preservation practices. The well-preserved homes of presidents and extraordinary examples of architecture, known worldwide, dominate our landscape. We see daily the many ways in which preservation work enriches the lives of people who live in, work in, and visit our community. Numerous residents in the P...

Insoluble Dendronized Chitosan (DCTS) was prepared to improve the adsorption capacity of chitosan (CTS) as well as to lower its solubility at lower pH for efficient removal of acid dye, Acid Blue 9 (AB 9) from aqueous solutions. Dendronized chitosan was prepared by grafting ‘dendrimer-like’ Polyamidoamine (PAMAM) onto CTS surface using Michael addition reaction followed by amidation reaction. T...

Conventional light microscopy techniques are poorly suited for imaging the vertical cell dimension. This can be accomplished using transmission-through-dye (TTD) imaging, in which cell thickness is directly converted into image intensity in the presence of extracellular dye with strong absorption. We have previously described applications of TTD to living cells using the dye Acid Blue 9 (AB9) t...