PURPOSE Asthma is a chronic airway disease characterized by airway remodeling, leading to a progressive decline in lung function. Therapeutic agents that attenuate airway remodeling can complement the limited effects of traditional glucocorticoids. In this study, we investigated the effect of resveratrol on allergic airway inflammation and remodeling in a murine model of chronic bronchial asthm...

Chronic airway inflammation, one of the pathophysiologic features of bronchial asthma, is suspected to be responsible for irreversible pathological changes of airways, called airway remodeling. To examine the mechanisms of airway remodeling in asthma, we investigated the expression of epidermal growth factor (EGF) and its receptor immunohistochemically in asthmatic human airways. Airway specime...

It is increasingly recognised that the airway circulation plays an important role in airway diseases, either through a change in blood flow or through microvascular leakage. Most of the information available regarding the anatomy and physiology of bronchial blood flow and its regulation has necessarily derived from animal studies. However, there have recently been important advances in understa...

Bronchial asthma (BA) among children is an important health issue worldwide, including Bulgaria. The prevalence is increasing although the reasons are poorly understood. The common characteristics of asthma include bronchial spasm, airway remodeling with variable narrowing, bronchial hyperresponsiveness, and airway inflammation. One of the key pathogenetic mechanisms is the disturbance of the p...

Bronchial Asthma is an airway disease with variable degrees of bronchial mucosal inflammation and intermittent episodes of airway obstruction and bronchial hyperesponsivness. That asthma is a syndrome consisting of different phenotypes has been recognized for a long time by clinicians [1]. New evidence indicates that the composition of airway microbiota differs in states of health and disease. ...

MYSIR’s Abstracts 21. EP01: LARGEST CASE SERIES OF FLEXIBLE BRONCHOSCOPY REMOVAL ASPIRATED SCARF PINS 2. EP02: TO COMPARE THE EFFICACY AND DIAGNOSTIC YIELD BRONCHOSCOPIC BIOPSY USING CONVENTIONAL FORCEPS VERSUS 1.1MM CRYOPROBE IN CENTRAL AIRWAY LESION 3. EP03: PREDICTIVE RISK FACTORS FOR PNEUMOTHORAX AFTER FLUOROSCOPIC GUIDED TRANSBRONCHIAL LUNG 4. EP04: BRONCHIAL WASHING BRONCHOALVEOLAR LAVAGE...

BACKGROUND The anatomical configurations of respiratory tract would be directly associated with their ventilatory function. It is necessary to fully understand the association between airway configurations and their functions as well as the interactions between different airway segments. In this study, we developed a respiratory airway model to investigate the effects of bronchial structural ab...

Introduction: Fibroepithelial polyp (FEP) is a benign tumor that presented frequently in some of the organs like oral cavity, skin, colon and genitourinary tract, but airway rare. Case Presentation: We present rare case this paper, with recurrent bronchial FEP was near completely obstructed right main bronchus we managed her successfully interventional bronchoscopy. In report describe condition...

BACKGROUND: Bronchial Thermoplasty, a procedure that applies thermal energy to the airway wall has been shown to impair the ability of airway to contract in response to methacholine chloride (Mch). The technique has been advocated as an alternative treatment for asthma that may permanently limit airway narrowing. In previous experimental studies in dogs and humans, it was shown that those airwa...

The apparent discrepancy between the reported preferential occurrence of bronchial carcinomas in central bronchial airways and current dose estimates for inhaled particles suggests that experimentally observed local accumulations of particles within bronchial airway bifurcations may play a crucial role in lung cancer induction. Here, we computed three-dimensional particle deposition patterns in...