نتایج جستجو برای: bruton
تعداد نتایج: 389 فیلتر نتایج به سال:
The development of a chronic polioencephalitis is reported in a patient with infantile X-linked hypogammaglobulinaemia (IXH Bruton type agammaglobulinaemia). In early childhood, the patient had multiple episodes of purulent inflammation involving the meninges and respiratory tract. He was given continuous administration of gammaglobulin and intermittent treatment with antibiotics, and survived ...
The following conditions and diseases that are associated with primary immunodeficiency disorder include, Combined variable immunodeficiency disease, Ataxia-telangiectasia, Chediak-Higashi syndrome, Complement deficiencies, DiGeorge syndrome, Hypogammaglobulinemia, Job syndrome, Leukocyte adhesion defects, Bruton disease, Congenital agammaglobulinemia, Selective deficiency of IgA, Wiscott-Aldri...
A beamforming system based on two-dimensional (2-D) spatially bandpass infinite impulse response (IIR) plane wave filtering is presented in a multi-dimensional signal processing perspective and the implementation details are discussed. Real-time implementation of such beamforming systems requires modeling of computational electromagnetics for the antennas, radio frequency (RF) analog design asp...
5 Garry Bruton, David Ahlstrom, Kuang S. Yeh 6 Department of Management, M.J. Neeley School of Business, Texas Christian University, P.O. Box 298530, Fort Worth, TX 76129, USA 7 Department of Management, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China 8 Pacific Broadband Co., Ltd., Taipei, Taiwan 9 Department of Business Management, National Sun Yat-sen University, Kaohsiung, ...
Ibrutinib is an oral irreversible inhibitor of the bruton tyrosine kinase (Btk) which has shown promising efficacy and excellent tolerability in patients with chronic lymphocytic leukemia (CLL) and other B-cell malignancies. Ibrutinib inhibits BCR signaling, impairs chemokine-mediated adhesion and migration, and induces moderate levels of apoptosis on CLL cells. It also reduces TCR downstream a...
The authors describe two patients with Bruton-type agammaglobulinemia, their purpose being to indicate the spectrum of findings, clinical and imaging. MR in one patient revealed diffuse leptomeningeal enhancement in the brain and spine; in the second patient, a heterogeneous mass was seen that had broken through the basiocciput and displaced a cerebellar hemisphere. Awareness of the common and ...
Ibrutinib (ibr), a first-in-class Bruton tyrosine kinase (BTK) inhibitor, has demonstrated high response rates in both relapsed/refractory and treatment naïve chronic lymphocytic leukemia (CLL). However, about 25% of patients discontinue ibrutinib therapy at a median follow-up of 20 months and many patients discontinue the treatment due to leukemia progression or Richter transformation. Mutatio...
Investing in new projects and technologies by mature firms is a challenging endeavour that often fails to create lasting significant growth for firms (Jensen, 1993). Investments in entrepreneurial ventures by outsiders such as venture capitalists that often rely on new technology can, however, be even more challenging (Christensen, 2000). Venture capitalists have found ways to reduce the risk a...
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