OBJECTIVE Bryonia aspera (Stev. ex Ledeb) is a plant that grows in northeast of Iran. In the present study, cytotoxic and apoptogenic properties of B. aspera root extract was determined against HN-5(head and neck squamous cell carcinoma) and Hela (cervix adenocarcinoma) cell lines. MATERIALS AND METHODS HN-5 and Hela cell lines were cultured in DMEM medium and incubated with different concent...

The 90% aqueous ethanol extract of an Egyptian natural medicine, the roots of Bryonia cretica L., was found to exhibit a strong inhibitory effect on the proliferation of human leukemia U937 cells. By bioassay-guided fractionation, we isolated two new cucurbitane-type triterpene glycosides, bryoniaosides A and B, were isolated from the roots of Bryonia cretica L. together with 16 known cucurbita...

conclusions the experimental data verified that hebd leaves displayed remarkable antinociceptive activity. furthermore, the nonselective opioid receptor antagonist, naloxone blocked the antinociceptive effect of the extract in all tests, suggesting that hebd may act both at peripheral and central levels. results using writhing, tail-flick, and formalin tests, dramatic antinociceptive effects wer...

Genetic crosses between the dioecious Bryonia dioica (Cucurbitaceae) and the monoecious B. alba in 1903 provided the first clear evidence for Mendelian inheritance of dioecy and made B. dioica the first organism for which XY sex-determination was experimentally proven. Applying molecular tools to this system, we developed a sex-linked sequence-characterized amplified region (SCAR) marker for B....

The effect of aqueous-ethanolic extract of Zataria multiflora Boiss (Labiatae), on βadrenoceptors was examined on tracheal chains of guinea pigs. The effects of three concentrations of aqueous-ethanolic extract (0.05, 0.1 and 0.2 mg/mL), 10 nM propranolol, and saline on β-adrenoceptors were tested (n=8). The results showed clear leftward shifts in isoprenaline curves obtained in the presence of...