BACKGROUND The efficacy and safety of axitinib, a potent and selective vascular endothelial growth factor receptors 1-3 inhibitor, combined with best supportive care (BSC) was evaluated in a global, randomized, placebo-controlled phase II trial in patients with locally advanced or metastatic hepatocellular carcinoma (HCC). PATIENTS AND METHODS Patients with HCC and Child-Pugh Class A who prog...

Despite the fact that since its launch by Kaplan and Norton (1992) professional and academic discourse on the Balanced Scorecard (BSC) is intense, it is not clear to what extent organizational changes are induced by and associated with this discourse. An intensive BSC-discourse may not be equated with a large amount of actual changes within organizations. This paper’s aim is to contribute to un...

BACKGROUND Academic hospitalist groups (AHGs) are often expected to excel in multiple domains: quality improvement, patient safety, education, research, administration, and clinical care. To be successful, AHGs must develop strategies to balance their energies, resources, and performance. The balanced scorecard (BSC) is a strategic management system that enables organizations to translate their...

The Balanced Scorecard (BSC), as a strategic management and control tool with an integrated set of leading and lagging performance measures, can secure successful implementation of purchasing strategies. However, the quality of the BSC itself as well as the effectiveness of the process to set up, implement, and use the BSC are crucial. Recognizing the growing importance of the purchasing-BSC (P...

gene, however, progression-free survival was nearly doubled in the cetuximab/BSC group at 3.8 months, compared with 1.8 months in the BSC-alone group (P < 0.0001). For the primary endpoint of overall survival, again among patients with mutated K-ras genes, findings were similar: 4.5 months for cetuximab plus BSC and 4.6 months for BSC alone (P = 0.89). For wild-type K-ras, there was a significa...

In this article, we focus on the Balanced Scorecard (BSC) as a discursive practice. Instead of asking whether the figures in the BSC correspond to reality, or whether they serve the users’ purposes and behave according to their intentions, we have chosen to analyse how the BSC partakes in shaping the world it is intended to reflect. Two case studies will be presented in order to demonstrate how...

We consider Bott-Samelson varieties BSc(s) for a semisimple compact Lie group C corresponding to sequences of (not necessarily simple) reflections s. Let n be the length s, K maximal torus in and W Weyl C. For any set R not overlapping integer pairs (i,j) such that 1?i?j?n function v:R?W, we subspace BSc(s,v)?BSc(s) solutions equations C/K requiring K-orbit product coordinates counted from i j ...

GSM networks are very expensive. The network design process requires too many decisions in a combinatorial explosion. For this reason, the larger is the network, the harder is to achieve a totally human based optimized solution. The BSC (Base Station Control) nodes have to be geographically well allocated to reduce the transmission costs. There are decisions of association between BTS and BSC t...

This paper looks at capacity achieving detection strategies for information transfer over time-varying channels. The time-varying binary symmetric channel (TV-BSC) is identified as the basic binary state-space model. Separation of entropies principles and the TV-BSC model-based state-space approach are used to determine the performance bounds for coherent and non-coherent detection over time-va...

Inter-Rater Reliability and Downstream Financial Implications of Electrocardiography Screening in Young Athletes Harshil Dhutia, BSc, MRCP; Aneil Malhotra, BSc, MRCP, PhD; Tee Joo Yeo, MRCP; Irina Chis Ster, MSc, PhD; Vincent Gabus, MD; Alexandros Steriotis, MD; Helder Dores, MD; Greg Mellor, MB BChir, MRCP; Carmen García-Corrales, MD; Bode Ensam, MRCP; Viknesh Jayalapan, MRCP; Vivienne Anne Ez...