Purpose: The aim of study was to determine the relation vitamin D receptor gene (VDR) polymorphisms TaqI (rs731236), ApaI (rs7975232), BsmI (rs1544410), FokI (rs10735810) with risk obesity, metabolic syndrome and hepatosteatosis in children.Materials methods: 130 obese healthy children age range between 10-16 years included this study. Anthropometric measurements, biochemical evaluations abdomi...

PURPOSE To evaluate the association between the BsmI polymorphism and vascular risk factors or metabolic syndrome in patients with epilepsy treated with valproate. METHODS We performed a cross-sectional study to determine glucose homeostasis, lipid profile, and evidence of metabolic syndrome, as well as the BsmI polymorphism in seizure free adults with epilepsy. RESULTS We recruited 75 pati...

background: to evaluate vdr gene variation and its interaction with immune regulatory molecules in osteoporosis. methods: totally 205 pre and postmenopausal women were recruited in the study. after an overnight fast, peripheral blood was taken and centrifuged to sprat serum for measurement of serum parathyroid hormone, 25 hydroxyvitamin d, osteocal­cin and cross laps. the fok i polymorphism in ...

BACKGROUND The active metabolite (1, 25-dihydroxycholecalciferol) of vitamin D (25-hydroxycholecalciferol) leads to activation of macrophages and deficiency of vitamin D seems to be involved in the risk of tuberculosis. The effects of vitamin D are exerted by interaction with the vitamin D receptor (VDR) and may be influenced by polymorphism in the VDR gene. In this study, variation in the VDR ...

Introduction. Vitamin D deficiency may be an independent predictor of coronary heart disease (CHD) and the severity atherosclerosis. The results studies association various polymorphisms vitamin receptor ( VDR ) gene with risk CHD are contradictory, which necessitates study genetic variants characteristics clinical course in Russian population. objective was to determine distribution genotypes ...

Background: We explored the effect of vitamin D receptor gene (VDR) polymorphisms in response to PEG-IFN treatment in Egyptian chronic hepatitis B (CHB) patients. Methods: Two hundred hepatitis B virus (HBV) patients (42.3±10.7 years) on PEG-IFN α-2a (180 μg /kg for 48 weeks) and one hundred control subjects (37.3 ±12 years) were enrolled in the study. Vitamin D levels a...

Abstract Introduction Crohn’s disease (CD) and ulcerative colitis (UC) are chronic inflammatory conditions of the gastrointestinal tract. Studies have shown that polymorphisms vitamin D receptor (VDR) gene may help elucidate pathogenesis CD. Objectives To analyze role VDR (ApaI, BsmI, FokI, TaqI) in development Methods The present study is a systematic review with meta-analysis. total 50 articl...

BACKGROUND Vitamin D receptor (VDR) gene polymorphisms are possibly involved in the development of type 1 diabetes mellitus (T1DM). However, the results to date have been inconclusive. We performed a meta-analysis to examine the association between 2 polymorphisms (FokI and BsmI) of the VDR gene and T1DM in the Asian population. METHODS Literature was retrieved from PubMed, Web of Science, CB...

The BsmI polymorphism of the vitamin D receptor (VDR) gene influences mineral metabolism and the course of cancers and infections. The poly-A polymorphism is in linkage disequilibrium with BsmI and could be responsible for clinical associations attributed to BsmI. The objective of this work is to study the influence of VDR polymorphisms on survival of 143 prevalent hemodialysis (HD) patients fo...

The vitamin D (1,25-dihydroxyvitamin D3) receptor (VDR) gene encodes a protein that functions in the transcriptional regulation of vitamin D-responsive genes and plays a role in innate immunity and adaptive immune responses. In this study, we investigated the relationship between VDR polymorphisms (BsmI, ApaI, and TaqI) and primary biliary cirrhosis (PBC) risk. We conducted an overall meta-anal...