Case I An 11-year-old male presented with a two-month history of abdominal pain and wasting and a one-month history of abdominal distension. He was otherwise fit and well with no significant past medical or family history. He was on no medications and had no known allergies. On examination he was wasted with a weight of 19 kilograms. His abdomen was moderately distended with a huge tender mass ...

Latently infected Kaposi’s sarcoma-associated herpesvirus (KSHV)-associated tumor cells have both endothelial and lymphoid origins and express a limited set of latent viral genes. One such gene, ORF73, encodes the latency-associated nuclear antigen (LANA), a multifunctional protein that plays roles in viral DNA replication, episome maintenance, and transcriptional regulation. LANA interacts wit...

We compared the effects of phosphorylation of Oct-2 protein on its binding to the consensus octamer sequence (ATGCAAAT) and two non-canonical sequences present in human (AAGCAAAT) and murine (AAACAAAT) promoters of the BLR1 (Burkitts' lymphoma receptor 1) gene encoding chemokine receptor CXCR5 (CXC-chemokine receptor 5). The latter cis-acting elements represent low-affinity recognition sequence...

Latently infected Kaposi's sarcoma-associated herpes-virus (KSHV)-associated tumor cells have both endothelial and lymphoid origins and express a limited set of latent viral genes. One such gene, ORF73, encodes the latency-associated nuclear antigen (LANA), a multifunctional protein that plays roles in viral DNA replication, episome maintenance, and transcriptional regulation. LANA interacts wi...

Jelinek et al raise some important questions about the impact of lifestyle factors on disease progression in multiple sclerosis (MS). Different patterns of MS conform to Burkitts’ definition of a ‘disease of modern Western civilization’, though the evidence to support an ‘autoimmune’ aetiology is limited. MS presenting as neuromyelitis optica is an emerging pattern of the disease in nonWestern ...

OBJECTIVE To investigate the effect of down-regulation of Sentrin/SUMO-specific protease 1 (SENP1) expression on the apoptosis of human Burkitt lymphoma cells (Daudi cells) and potential mechanisms. METHODS Short hairpin RNA (shRNA) targeting SENP1 was designed and synthesized and then cloned into a lentiviral vector. A lentiviral packaging plasmid was used to transfect Daudi cells (sh-SENP1-...

INTRODUCTION The mandible and maxilla can be the site of myriads of lesions that may be categorized as neoplastic, cystic, reactive and infective or inflammatory. Literature reviewing jaw swellings in an amalgamated fashion are uncommon, probably because aetiologies for these swellings are varied. However, to appreciate their relative relationship, it is essential to evaluate the clinico-pathol...

1532-Pos Board B302 Quantitative Scheme for Full-Field Polarization Rotating Fluorescence Microscopy (PROM) using a Liquid Crystal Variable Retarder John F. Lesoine. National Institute of Standards and Technology, Gaithersburg, MD, USA. We present a quantitative scheme for full-field polarization rotating fluorescence microscopy (PROM). A quarter-wave plate, in combination with a liquid crystal...

non-hodgkin lymphoma usually presents with generalized lymphadenopathy, but it can also involve any part of the human body. lymphomatous involvement of muscles is a rare presentation and has been reported to occur in only 1.1% in non-hodgkin lymphoma. here we, present a 32 year-old iranian man with primary involvement of spleen, bone, bone marrow and muscle, mimicking soft tissue sarcoma; core ...