The leaves of three Ligularia species belonging to the family Compositae, Ligularia stenocephala, L. fischeri, and L. fischeri var. spiciformis, were qualitatively and quantitatively analyzed on the caffeoylquinic acids by HPLC and subjected to peroxynitrite-scavenging assay. The IC(50) of the MeOH extract of L. stenocephala was 1.62+/-0.03 mug/ml and the major caffeoylquinic acids of L. stenoc...

From the ethyl acetate soluble fraction of a methanol/water extract of the herb Eupatorium perfoliatum L. (Asteraceae) six caffeic acid derivatives have been isolated and identified by 1D- and 2D-NMR spectroscopic data. Besides the common quinic acid derivatives 5-caffeoylquinic acid (chlorogenic acid), 3-caffeoylquinic acid (neochlorogenic acid) and 3,5-dicaffeoylquinic acid, three up to now u...

Abstract In this study, we investigated the effects of dicaffeoylquinic acid derivatives, including 1,4-di-O-caffeoylquinic (1,4-DCQA), 3,4-di-O-caffeoylquinic (3,4-DCQA), 3,5-di-O-caffeoylquinic (3,5-DCQA), 4,5-di-O-caffeoylquinic (4,5-DCQA), and 1,5-di-O-caffeoylquinic (1,5-DCQA) on glucose-stimulated insulin secretion (GSIS) activity α-glucosidase were compared in rat INS-1 pancreatic β-cell...

The influence of different brewing conditions on the concentration of the main caffeoylquinic acids (3-caffeoylquinic acid (3-CQA), 4-caffeoylquinic acid (4-CQA), and 5-caffeoylquinic acid (5-CQA)) was investigated. For this purpose, twenty-four coffee brews were extracted and analyzed using HPLC-DAD at 325 nm. Our findings demonstrate the great impact of brewing techniques on the caffeoylquini...

Eleven hydroxycinnamic acid derivatives were isolated from a 70% methanolic Crataegus extract (Crataegi folium cum flore) and partly verified and quantified for individual Crataegus species (C. laevigata, C. monogyna, C. nigra, C. pentagyna) by HPLC: 3-O-(E)-p-coumaroylquinic acid (1), 5-O-(E)-p-coumaroyl-quinic acid (2), 4-O-(E)-p-coumaroylquinic acid (3), 3-O-(E)-caffeoylquinic acid (4), 4-O-...

Eight compounds isolated from Indian barnyard millet have been identified as L-malic acid, trans-aconitic acid, (+)-isocitric acid, 5-O-caffeoylquinic acid, 4-O-caffeoylquinic acid, isocarlinoside, 2"-O-rhamnosylisoorientin, and 7-O-(2"-O-glucuronosyl)glucuronosyltricin, respectively. These compounds showed high antifeeding activity against brown planthopper only when they were combined.

Burdock roots are healthy dietary supplements and a kind of famous traditional Chinese medicine, which contains large amounts of caffeoylquinic acid derivatives. However, little research has been reported on the preparative separation of these compounds from burdock roots. In the present study, a combinative method of HSCCC and semi-preparative HPLC was developed for the semi-preparative separa...

In this study, caffeic acid (CA) and its three derivatives including 3-caffeoylquinic acid (3-CQA, neochlorogenic acid), 4-caffeoylquinic acid (4-CQA, cryptochlorogenic acid), and 5-caffeoylquinic acid (5-CQA, chlorogenic acid) were identified in Bupleurum chinense aerial parts using reverse-phase high-performance liquid chromatography (RP-HPLC) with photodiode array (PDA) detector, reference c...

dorema glabrum fisch. & c.a. mey. (apiaceae) is a monocarpic perennial plant distributed in southern caucasus. in azerbaijan republic folk medicine, the gum-resin of this species is used as a diuretic and anti-diarrheal agent. it is also traditionally used for the treatment of bronchitis and catarrh. in the present study, chemical constituents of the essential oil and extract of d. glabrum aeri...

Plants of the genus Taraxacum Wigg., have long been used as medicinal herbs. A phytochemical investigation of the aerial parts of Taraxacum bessarabicum (Hornem.) Hand.-Mazz. subsp. bessarabicum (Hornem.) Hand.-Mazz. (Asteraceae) yielded two coumarins [esculetin (1), cichoriin (2)], three flavonoids [ luteolin (3), luteolin 7-O-β-D-glucoside (4), gossypetin (5)] and six phenolic acids and their...