Chronic exposure to lead (Pb) affects neural functions in central nervous system (CNS) particularly the learning and memory. On the other hand, alteration of calcium level in the CNS results in activation of NOS. It has been shown that lead enters the neurons through calcium channels and displaces Ca2+ from calcium binding proteins such as calmodulin and troponin C thereby affecting calcium-med...

Dr. Troels Ring, MD, Medical Department C, Aalborg Hospital, Aalborg (Denmark) Dear Sir, Two recent papers comparing calcium carbonate with calcium acetate both conclude that calcium acetate is the better phosphorus binder. In the paper by Caravaca et al. [1], the serum phosphate concentration was 1.80 ± 0.50 (SD) mmol/l while on calcium acetate, and 1.93 ± 0.48 on calcium carbonate in a parall...

Dr. Troels Ring, MD, Medical Department C, Aalborg Hospital, Aalborg (Denmark) Dear Sir, Two recent papers comparing calcium carbonate with calcium acetate both conclude that calcium acetate is the better phosphorus binder. In the paper by Caravaca et al. [1], the serum phosphate concentration was 1.80 ± 0.50 (SD) mmol/l while on calcium acetate, and 1.93 ± 0.48 on calcium carbonate in a parall...

Dr. Troels Ring, MD, Medical Department C, Aalborg Hospital, Aalborg (Denmark) Dear Sir, Two recent papers comparing calcium carbonate with calcium acetate both conclude that calcium acetate is the better phosphorus binder. In the paper by Caravaca et al. [1], the serum phosphate concentration was 1.80 ± 0.50 (SD) mmol/l while on calcium acetate, and 1.93 ± 0.48 on calcium carbonate in a parall...

CONTEXT Hyperphosphatemia has an important role in the development of bone and mineral abnormalities in end-stage renal disease (ESRD). OBJECTIVE To compare the phosphorus binding power and the hypercalcemic effect of calcium acetate and calcium carbonate in hemodialysis patients. TYPE OF STUDY Crossover, randomized, double-blind study. PLACE A private hospital dialysis center. PARTICIP...

We compared the effectiveness of calcium acetate as a phosphate binder with that of calcium carbonate by substituting one for the other in patients undergoing continuous ambulatory peritoneal dialysis. Twenty patients who had been receiving calcium carbonate as a phosphate binder were instead given calcium acetate, initially with two thirds of the previous dose of elemental calcium. The calcium...

The phorbol ester 12-O-tetradecanoyl phorbol-13-acetate was used to probe the role of protein kinase-C in the modulation of a-adrenergic receptor-coupled calcium efflux in cultured vascular smooth muscle cells derived from rabbit aorta. Exposure of cells to 12-O-tetradecanoyl phorbol-13-acetate for 6 minutes caused a concentration-related (maximum effect at >10 tat) increase in calcium-45 efflu...

OBJECTIVES The tolerability and efficacy of lanthanum carbonate has not been studied in the Indian population. This study was, therefore, undertaken to compare the efficacy and tolerability of lanthanum carbonate with calcium acetate in patients with stage 4 chronic kidney disease. DESIGN A randomized open label two group cross-over study. MATERIALS AND METHODS Following Institutional Ethic...

The chemotactic peptide formylmethionylleucylphenylalanine rapidly elevated the intracellular calcium concentration, in a concentration-dependent manner, of human leukemic (HL-60) cells which had been differentiated to polymorphonuclear leukocyte-like cells by pretreatment with dimethyl sulfoxide (1.3%). Preincubation of the cells with phorbol 12-myristate 13-acetate, a protein kinase C-activat...