Calcium phosphate nanoparticles present a unique class of non-viral vectors, which can serve as efficient and alternative DNA carriers for targeted delivery of genes. In this study we report the design and synthesis of ultra-low size, highly monodispersed DNA doped calcium phosphate nanoparticles of size around 80 nm in diameter. The DNA encapsulated inside the nanoparticle is protected from th...

Cytotoxicity of Calcium Phosphate Crystals and Human-Derived Nanoparticles: An Overlooked Link To the Editor: In a recent communication, Ewence et al reported that calcium phosphate crystals induced cell death in human aortic vascular smooth muscle cells. Explicitly, crystals of approximately 1 m in diameter caused rapid rises in intracellular calcium concentration, their potency depending on t...

Calcium phosphate nanoparticles are safe and effective delivery vehicles for small interfering RNA (siRNA), as a result of their excellent biocompatibility. In this work, mPEG-PE (polyethylene glycol-L-α-phosphatidylethanolamine) was synthesized and used to prepare nanoparticles composed of mPEG-PE and calcium phosphate for siRNA delivery. Calcium phosphate and mPEG-PE formed the stable hybrid ...

Calcium phosphate nanoparticles are suitable as scaffolds for bone regeneration; however, few reports on available calcium phosphate-based biomaterials with an antibacterial property drug carriers. Lei Nie and colleagues developed silver-doped biphasic phosphate/alginate microclusters using the double-emulsions method. The cover image shows SEM micrograph of prepared in which spherical shape su...

The crystallization of calcium phosphate nanoparticles in the presence carboxylates was characterized situ through simultaneous SAXS/WAXS using synchrotron light.

Application of therapeutic gene transfer in the treatment of genetic diseases is a notable progress but there are some disadvantages and limitations in it. The process of overcoming these barriers is a drastic change in gene delivery. Recently, calcium phosphate nanoparticles alone, or in combination with viral and nonviral vectors, were found to have a positive effect on gene transfer especial...

Magnetic mesoporous amorphous calcium phosphate nanoparticles with a size of 62 nm and abundant -COOH groups on the surface have been prepared by a simple method. The particles show excellent aqueous dispersion stability in physiological pH without any deterioration in hydrodynamic size and zetapotential. By virtue of the carboxylate groups on the surface, the platinum pharmacophore cis-diaquad...

Due to the similar chemical properties to the inorganic component in calcified tissues, synthetic calcium phosphate has been considered as ideal biomaterials with excellent biocompatibility. Nanostructured calcium phosphate materials play an important role in the formation of hard tissues in nature. It is reported that calcium phosphates materials in nano-size can mimic the dimensions of consti...

This paper describes a method for preparing chitosan fibers modified with hydroxyapatite (HAp), tricalcium phosphate (β-TCP), and HAp/β-TCP nanoparticles. Fiber-grade chitosan derived from the northern shrimp (Pandalus borealis) and nanoparticles of tricalcium phosphate (β-TCP) and hydroxyapatite (HAp) suspended in a diluted chitosan solution were used in the investigation. Diluted chitosan sol...

The concurrent release of calcium phosphate and biomacromolecules may improve wound healing responses at the interface with ceramic materials of orthopaedic and dental implants. Hydrogel coatings consisting of a mixture of alginate and chitosan were doped and applied onto solid carriers with the aim of investigating their use as local delivery vehicles. Coatings containing both the model macrom...