Bulk shear viscosities were measured with a cone and plate microviscometer as a function of concentration, shear rate, and temperature for lavaged calf lung surfactant (LS), Exosurf, Infasurf, Survanta, and synthetic lipid mixtures dispersed in normal saline. Viscosity increased with phospholipid concentration for all surfactants, but its magnitude and shear dependence varied widely among the d...

BACKGROUND This study examines the surface activity and resistance to phospholipase degradation of a fully-synthetic lung surfactant containing a novel diether phosphonolipid (DEPN-8) plus a 34 amino acid peptide (Mini-B) related to native surfactant protein (SP)-B. Activity studies used adsorption, pulsating bubble, and captive bubble methods to assess a range of surface behaviors, supplemente...

OBJECTIVE This study was undertaken to investigate the effects of recombinant human epidermal growth factor (rhEGF) and protein-free calf blood extract on corneal wound healing and neovascularization. MATERIALS AND METHODS An rabbit central corneal wound and neovascularization model was established in rabbits. One eye of each group was chosen randomly for topical administration of protein-fre...

this study was done for identification of bacterial agents in calf pneumonia and determination of their antimicrobial susceptibility. bronchoalveolar lavage was done on fourteen pneumonic and seven normal holstein calves between 1-3 month old. in bacteriological examination on the fluid of bronchoalveolar lavage, mycoplasma spp. were isolated from 4 (28.6%) pneumonic calves and 1 (14.3%) health...

BACKGROUND Respiratory distress syndrome (RDS) is currently treated with surfactant preparations obtained from natural sources and attempts to develop equally active synthetic surfactants have been unsuccessful. One difference in composition is that naturally derived surfactants contain the two hydrophobic proteins SP-B and SP-C while synthetic preparations contain analogues of either SP-B or S...

Background. Chemical spills are on the rise and inhalation of toxic chemicals may induce chemical acute lung injury (ALI)/acute respiratory distress syndrome (ARDS). Although the pathophysiology of ALI/ARDS is well understood, the absence of specific antidotes has limited the effectiveness of therapeutic interventions. Objectives. Surfactant inactivation and formation of free radicals are impor...

a three month-old-male red deer calf (cervus elaphus maral) was examined post mortem for the cause of death in arasbaran preserved area in east azerbaijan in september 2006. the main history of the case was the lack of colostrum intake after birth. the necropsy 6 hours after death, revealed severe general congestion especially in lungs and visceral organs (liver and jejunum). the cut surface of...