The authors describe the use of a porous polyethylene Flexblock implant for cosmetic cranioplasty. The implant may be used to cover any small- or medium-sized (< 8 cm) cranial defect, offering similar cosmetic results to standard alloplast cranioplasty while decreasing operation time. The porous implant design permits ingrowth of soft tissue and bone to increase implant strength and decrease th...

We describe the unilateral occurrence of 14 and 6 Hz positive bursts in successive EEGs in a 25-year-old woman following surgical resection of a left parietal arteriovenous malformation which had caused a left parieto-temporal intracerebral hematoma. This is only the second reported case of unilateral 14 and 6 Hz positive bursts. This could represent either a normal pattern seen unilaterally be...

Secreted frizzled-related protein (sFRP)-3 is a negative regulator of Wnt signaling in human mesenchymal stem cells (hMSCs). The present study investigated the effects sFRP-3 on osteogenic differentiation by assessing osteogenic gene expression in hMSCs in vitro and by examining bone regeneration in a rat bone defect model. sFRP-3 treatment induced osteogenic differentiation in hMSCs as determi...

Growing skull fracture is a rare complication of head injury in which 90% of the cases occur among children less than 3 years old. Only two cases have been reported in the adult population [1, 2]. We report a rounded lytic skull defect in a 75-year-old man that was surgically and pathologically determined to be a growing skull fracture despite a deceptive radiologic appearance simulating a lyti...

DESCRIPTION A 61-year-old man presents with invasive basal cell carcinoma of the scalp. Composite resection results in a 280-cm 2 scalp defect of the outer and inner table. Titanium mesh was used to reconstruct the calvarial defect, while reconstruction of the scalp wound was accomplished with a free latissimus dorsi (LD) flap plus split-thickness skin graft.

Craniofacial injuries can result from trauma, tumor ablation, or infection and may require multiple surgical revisions. To address the challenges associated with treating craniofacial bone defects, an ideal material should have the ability to fit complex defects (i.e. be conformable), provide temporary protection to the brain until the bone heals, and enhance tissue regeneration with the delive...

Bone tissue engineering is based on bone grafting to repair bone defects. Bone graft substitutes can contribute to the addition of mesenchymal stem cells (MSCs) in order to enhance the rate and the quality of defect regeneration. The stem cell secretome contains many growth factors and chemokines, which could affect cellular characteristics and behavior. Conditioned medium (CM) could be used in...

Objective: The aim of this study is to describe our experience with cranioplasty plus using implantable biomaterials in repairing calvarial defect, and to highlight its necessity in treating this

BACKGROUND Human adipose-derived stromal cells (hASCs) represent a multipotent cell stromal cell type with proven capacity to differentiate along an osteogenic lineage. This suggests that they may be used to heal defects of the craniofacial or appendicular skeleton. We sought to substantiate the use of undifferentiated hASCs in the regeneration of a non-healing mouse skeletal defect. METHODOL...

BACKGROUND Arginine silicate inositol complex (ASI; arginine 49.5%, silicon 8.2%, and inositol 25%) is a novel material that is a bioavailable source of silicon and arginine. ASI offers potential benefits for vascular and bone health. OBJECTIVE The aim of this study was to evaluate the potential effects of ASI complex on bone healing of critical-sized defects in rats. METHODS The rats were ...