Motility of the nerve growth cone is highly dependent on its dynamic interactions with the microenvironment mediated by cell adhesion molecules (CAMs). These adhesive interactions can be spatially regulated by changing the density and avidity of CAMs on the growth cone. Previous studies have shown that L1, a member of the immunoglobulin superfamily of CAMs, is endocytosed at the central domain ...

In contrast to the human lutropin receptor (hLHR), very few naturally occurring activating mutations of the structurally related human follitropin receptor (hFSHR) have been identified. The present study was undertaken to determine if one aspect underlying this discrepancy might be a general resistance of the hFSHR to mutation-induced constitutive activity. Five different mutations were introdu...

Cell-cell interactions mediated via cell adhesion molecules (CAMs) are dynamically regulated during nervous system development. One mechanism to control the amount of cell surface CAMs is to regulate their recycling from the plasma membrane. The L1 subfamily of CAMs has a highly conserved cytoplasmic domain that contains a tyrosine, followed by the alternatively spliced RSLE (Arg-Ser-Leu-Glu) s...

Immunoglobulin superfamily (IgSF) cell adhesion molecules (CAMs) are cell surface glycoproteins that not only mediate interactions between neurons but also between neurons and other cells in the nervous system. While typical IgSF CAMs are transmembrane molecules, this superfamily also includes CAMs, which do not possess transmembrane and intracellular domains and are instead attached to the pla...

The multiobjective optimization of Slide-o-Cam is reported in this paper. Slide-o-Cam is a cam mechanism with multiple rollers mounted on a common translating follower. This transmission provides pure-rolling motion, thereby reducing the friction of rack-and-pinions and linear drives. A Pareto frontier is obtained by means of multiobjective optimization. This optimization is based on three obje...

A continuously variable transmission (CVT) consisting of slider-cranks, solid cams and non-invertible mechanisms is discussed in this paper. The conventional CVTs are mainly classified as belt-types or toroidal types conduction mechanisms. Basically, these composed frictional components. However, the proposed CVT paper does not have any special friction conductions. Friction force which being o...

Nicotinic acid adenine dinucleotide phosphate (NAADP) is a potent intracellular Ca(2+) signalling second messenger, but the mechanism of NAADP-induced Ca(2+) release is still poorly understood. The present study tested the hypothesis that NAADP induces Ca(2+) release from the lysosomal store via a TRP-ML1 (transient receptor potential-mucolipin 1)-mediated Ca(2+) release channel in coronary art...

Nicotinic acid adenine dinucleotide phosphate (NAADP) is a potent intracellular Ca signalling second messenger, but the mechanism of NAADP-induced Ca release is still poorly understood. The present study tested the hypothesis that NAADP induces Ca release from the lysosomal store via a TRP-ML1 (transient receptor potential-mucolipin 1)-mediated Ca release channel in coronary arterial myocytes (...