background: the prevalence of colorectal cancer (crc) is rapidly increasing in iran. it holds the most prevalent cancer after skin, breast, and gastric cancers among the iranian population. the current study was designed to investigate the effects of leisure time, occupational and household physical activity as well as exercise on the risk of crc in the iranian population. methods: in this popu...

background: cancer has the highest disease-related mortality rate in iran. reduced activity of paraoxonase reported in patients with cancer may be due to a reduction in its antioxidant properties and a subsequent increased risk of developing cancer. we aimed to assess antioxidant and oxidative status in patients with cancer through measuring the activity of pon1 as an antioxidant enzyme and det...

prostate cancer is a major cause of morbidity and mortality in iran, yet there are few studies examining risk factors specific to the iranian context. we conducted a case-control study to explore risk factors for prostate cancer in mazandaran, iran from 2005 to 2008. the cases were 137 men with clinicopathologically confirmed prostate cancer. controls were 137 neighborhood and age match men wit...

objective(s):valproic acid (vpa), a drug used in the treatment of neurological disorders, has been shown to have cytotoxic effects on cancer cells through different mechanisms. telomerase, a ribonucleoprotein reverse transcriptase, is responsible for elongation of the telomere and is activated in cancers. a relation between telomerase activity and resistance to apoptosis has been established. t...

background: the present study was performed to investigate the effects of trace elements particularity se, zn and cu on tumor genesis in breast cancer. methods: the inhibitory effect of se, zn and cu, on telomerase activity was analyzed in human breast tumor tissues and breast cancer (t47d) cells. tissue specimens from 24 women with benign breast disease and 32 women with breast cancer specimen...