N-acetyltryptophan (AT) and caprylic acid (Cap) are known to suppress the heat-induced aggregation of serum albumins. In this study, we examined the commonality of AT and Cap on the protein aggregation using hen egg-white lysozyme, ovalbumin, and bovine γ-globulin (BGG), as well as bovine and human serum albumin. AT and Cap as additives increased the unfolding temperatures of human and bovine a...

BACKGROUND Our aims were to evaluate the performance of a fully automated system for measuring circulating allergen-specific IgE (sIgE) against an established in vitro assay and to assess the system's diagnostic accuracy against objective clinical criteria for identifying sensitization to specific allergens. METHODS Using both the IMMULITE 2000 Allergy system (IML) and an assay based on the w...

INTRODUCTION Diagnosis of prostatic diseases with Immunohistochemistry still faces challenges because of the peculiar histology of the prostate and difference(s) in reactivity of Monoclonal antibodies (MoAb) to benign and malignant changes. METHODS Thirty (30) archived paraffin embedded tissue samples from primary prostate tumors (15 Benign Prostatic Hyperplasia (BPH) and 15 Cancer of the pro...

We applied flow cytometric analysis to characterize the in vitro response of alveolar macrophages (AM) to air pollution particulates. Normal hamster AM were incubated with varying concentrations of residual oil fly ash (ROFA) or concentrated ambient air particulates (CAP). We found a dose-dependent increase in AM-associated right angle light scatter (RAS) after uptake of ROFA (e.g., mean channe...

In the present study, we evaluated and compared serum markers of bone turnover in dialyzed patients with serum intact parathyroid hormone (iPTH) < 100 pg/mL (LBT group, n = 9), 100-150 pg/mL (MIX group, n = 6), and iPTH > 150 pg/mL (non-LBT group, n = 15). Laboratory parameters included iPTH; cyclase activating parathyroid hormone (CAP); osteoprotegerin (OPG); OPG ligand (OPGL); inorganic phosp...

A proline-directed serine/threonine ceramide-activated protein (CAP) kinase mediates transmembrane signaling through the sphingomyelin pathway. CAP kinase reportedly initiates proinflammatory TNF alpha action by phosphorylating and activating Raf-1. The present studies delineate kinase suppressor of Ras (KSR), identified genetically in Caenorhabditis elegans and Drosophila, as CAP kinase. Mouse...

Twenty-one patients with advanced breast cancer (7 premenopausal and 14 postmenopausal women) were treated with a combination of cyclophosphamide, doxorubicin, and cisplatin (CAP). The median age of the patients was 43 years (range 36-61). This therapy was repeated every 3 weeks. Nine patients (group 1) received CAP as primary therapy for metastatic breast cancer, and twelve patients (group...

BACKGROUND AND PURPOSE The efficacy of superficial temporal artery-middle cerebral artery (STA-MCA) anastomosis in adult moyamoya disease was evaluated by clinicopathophysiological studies. METHODS Fifteen patients with cerebral ischemic attacks (ischemia group) and 15 patients with intracranial hemorrhages (hemorrhage group) were investigated. Clinicoangiographic features and regional cerebr...

Both community acquired pneumonia (CAP) and diabetes mellitus are common in Bangladesh. Though hospitalization of diabetic patients with CAP is increasing, data regarding their clinical presentation, microbial characteristics, antimicrobial susceptibility and outcome are lacking. This study was aimed at finding any difference in clinical presentation, bacterial causes, antimicrobial susceptibil...