The transformation and cooling crystallization of anhydrate form (form III) and dihydrate form (CBZH) of carbamazepine (CBZ) have been investigated in this work. The two forms were unambiguously characterized with powder X-ray diffraction, Fourier transform infrared spectroscopy, Raman spectroscopy, scanning electron microscopy and thermal analysis. The solubility of the two forms in various al...

The present investigation is aimed to prepare the porous microspheres of carbamazepine using eudragit as release retardant, compritol as core forming agent, and HPMC as re-crystallization inhibitor for short-term sustained delivery of carbamazepine. The proposed microspheres were formulated using the emulsion solvent diffusion method. The obtained microspheres were characterized for its particl...

The effects of interaction between the solvent and CBZ on solubility polymorphic nucleation were discussed.

in this paper, differences in porosity, compressive strength and tablet- forming ability of carbamazepine crystals agglomerated under similar condition, but subjected to different drying temperatures are reported. the agglomerates were prepared by spherical crystallization method and thereafter dried without agitation at different temperature. an increased drying temperature did not affect the ...

The objective of this work was to study the polymorphic transformation of carbamazepine from Form II to Form III in 1-propanol during seeded isothermal batch crystallization. First, the pure Form II and Form III were obtained and characterized. Then their solubilities and metastable zone limits were measured by in-situ attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectrosc...

Objective(s):This study dealt with the wet agglomeration process in which a small quantity of binder liquid was added into a suspension of crystals, directly in the stirring vessel where the crystallization took place. The purpose of this investigation was evaluation of the effect of temperature on the agglomeration process in order to gain insight into the mechanism of the formation of the agg...

In this paper, differences in porosity, compressive strength and tablet- forming ability of carbamazepine crystals agglomerated under similar condition, but subjected to different drying temperatures are reported. The agglomerates were prepared by spherical crystallization method and thereafter dried without agitation at different temperature. An increased drying temperature did not affect the ...

The crystallization of an organic compound can produce a mixture of crystalline solids with different solid-state structures (polymorphs). No convenient method now exists to separate crystals of a single polymorph from a mixture of crystals of different polymorphs. Of the physical properties that might be used to separate polymorphs, density is attractive for two reasons: 1) Different packings ...

In this paper, an electrospray technique followed by annealing at high temperatures was developed to produce nanocrystals of carbamazepine (CBZ), a poorly water-soluble drug, for continuous pharmaceutical manufacturing process. Electrospraying solutions of CBZ in methanol obeys the expected scaling law of current, which is I ∼ Q(1/2) (I, electrical current; Q, flow rate), for liquids with suffi...