The aim of this work was to evaluate the performance of the new chromogenic medium BrillianceTM CREAgar (Thermo Fisher Scientific) for determining the limit of detection of carbapenem-resistant enterobacteria (CRE). A total of 70 clinical isolates were studied. Of these, 30 were well-characterized CRE, including Klebsiella pneumoniae strains producing KPC-, VIM-, and OXA-type enzymes, VIM-posit...

Introduction: Regarding the crucial role of geographic factors in different mechanisms underlying bacterial antibiotic resistance worldwide, it is necessary to design and conduct studies determine prevalence specific this phenomenon. Objectives: This study was performed assess carbapenem-resistant gram-negative bacilli which produce carbapenemase, Loghman Hakim hospital, Tehran. Patients Method...

Carbapenem-resistant Enterobacteriacea (CRE) has become a growing food safety issue and an ongoing public-health problem of global dimensions. This research study determined the presence CRE in fresh vegetables. Vegetables were purchased from retailers analyzed for Enterobacteriaceae line with Standard guidelines. The antibiotic profile isolated was using Antibiotic Susceptibility Test (AST). M...

We evaluated the number of deaths attributable to carbapenem-resistant Enterobacteriaceae by using studies from around the world published before April 9, 2012. Attributable death was defined as the difference in all-cause deaths between patients with carbapenem-resistant infections and those with carbapenem-susceptible infections. Online databases were searched, and data were qualitatively syn...

BACKGROUND We describe the prevalence of invasive carbapenem-resistant Acinetobacter spp. isolated from 2005 to 2016 in different regions of Switzerland. METHODS Using the Swiss Antibiotic Resistance Centre (anresis) database that includes data from 70% of all hospitalized patients and one third of all ambulatory practitioners in Switzerland, we analysed the number of carbapenem-susceptible a...

OBJECTIVES The objective of this study was to identify carbapenem-resistant organisms using routinely collected local microbiology data and describe the epidemiology of carbapenem resistance in two London teaching hospitals. METHODS Data on inpatients infected or colonized with Gram-negative organisms between March 2009 and February 2012 were extracted. A computer algorithm was developed inco...

Acinetobacter baumannii is an opportunistic gram-negative pathogen with increasing relevance in a variety of nosocomial infections especially among intensive-care-unit (ICU) patients. Carbapenems have been widely used to treat serious multidrug-resistant A. baumannii infections; however, incidences of carbapenem-resistant A. baumannii are rising in several parts of the world and large and susta...

Objective(s): Resistance to carbapenems is the principal reason for the continuing utilization of colistin as a last resort choice for treating the infections resulted from multidrug carbapenem-resistant Pseudomonas aeruginosa (CRPA) isolates. The assessment of antimicrobial resistance pattern, the prevalence of carbapenem-resistance determinants, and molecular epidemiology of colistin-resistan...

Carbapenem is an important therapy for serious hospital-acquired infections and the care of patients affected by multidrug-resistant organisms, specifically Acinetobacter baumannii; however, with global increase carbapenem-resistant A. baumannii, this pathogen has significantly threatened public health. Thus, there a pressing need to better understand in order develop novel treatments control s...