A novel DBU-mediated oxidative cyanation of α-amino carbonyl compounds by using air as the sole oxidant was developed under mild metal-free conditions for the first time. The reaction involves a tandem oxidation/Strecker reaction/oxidation process and provides a new and efficient method for the construction of α-iminonitriles in good to high yields in a single step.

1-Ethyl-3-methylimidazolium acetate is introduced as a robust organocatalyst for solvent-free cyanosilylation of carbonyl compounds with trimethylsilyl cyanide (TMSCN). The catalyst loading can be reduced to as low as 0.1-0.0001 mol % under mild reaction conditions, giving considerably high TOF values from 10,843 h-1 to 10,602,410 h-1 in the field of organocatalyzed transformations. The present...

[reaction: see text] A novel palladium-catalyzed coupling reaction between two Csp(3)-Csp(3) centers has been investigated. This protocol is initiated by the oxidative addition of an alpha-halo carbonyl compound to a palladium(0) species, followed by the double transmetalation. The key dialkyl palladium intermediate undergoes reductive elimination to form the desired coupling product.

1. Treatment of liver microsomal fraction with 0.03-0.12% sodium deoxycholate and 0.005-0.06 mM carbonyl cyanide m-chlorophenylhydrazone decreases phospholipid-dependent hydrophobicity of the microsomal membrane, assayed by the kinetics of 8-anilinonaphthalene-1-sulphonate binding and ethyl isocyanide difference spectra. 2. Sodium deoxycholate at a concentration of 0.01% lacks its detergent pro...

Corresponding Author: Steven Gabardi, PharmD, BCPS, FAST, FCCP, Abdominal Organ Transplant Clinical Specialist Departments of Transplant Surgery and Pharmacy Services, and the Renal Division, Brigham and Women’s Hospital, 75 Francis Street, Boston, MA 02115; Instructor in Medicine, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115; phone (617) 732-7658; fax (617) 732-7507; email sgab...

Jeffrey C. Delafuente, MS, FCCP, FASCP, associate dean for academic affairs and professor of pharmacotherapy, Virginia Commonwealth University School of Pharmacy, Richmond, Virginia, will assume the office of 2013-2014 president of the American Society of Consultant Pharmacists at the Society's 2013 Annual Meeting & Exhibition in November.

In an accompanying paper (l), it is shown that y-(p-arsenosophenyl)-n-butyrate activates the adenosine triphosphatase of both myosin and mitochondria, and several analogies between the properties of the active sites of these two energy transduction enzymes are discussed. Carbonyl cyanide p-chlorophenylhydrazone, which uncouples osidative phosphorylation at concentrations as low as lop7 &r (a), ...

The Rockefeller University Press $30.00 J. Cell Biol. Vol. 206 No. 5 655–670 www.jcb.org/cgi/doi/10.1083/jcb.201401070 JCB 655 Correspondence to Thomas L. Schwarz: [email protected] Abbreviations used in this paper: CCCP, carbonyl cyanide 3-chlorophenylhydrazone; CMV, cytomegalovirus; DIV, day in vitro; mt-KR, mitochondrial KillerRed; PD, Parkinson’s disease; ROS, reactive ox...