background: lung carcinoma is a multiple type cancer comprising of small cell and non-small cell carcinomas (nsclc). for therapeutic and diagnostic purposes, serum monoclonal antibodies have been produced against lung cancer. objective: to charac-terize a murine monoclonal antibody (me3d11) reactive with human nsclc. methods: a murine monoclonal antibody (me3d11) reactive with human nsclc was s...

background : e-cadherin is a trans-membrane glycoprotein that plays a critical role in many aspects of cell adhesion as well as establishment and maintenance of epithelial cell polarity. loss of the adhesive function of e-cadherin seems to promote invasive and metastatic properties of neoplastic cells.   objectives: the present study is a retrospective study aiming to evaluate the loss of e-cad...

background :cell proliferation is one of the most critical factors in metastasis and prognosis of the malignant tumors.recent investigations show that the eosinophil granolosytes have an important role in developing of malignant tumors. the relation between cell proliferation and eosinophilic infiltration in oral squamous cell carcinoma (oscs) with prognosis is unclear.the aim of this study was...

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AIMS To determine (1) the detection rate of primary carcinoma of the lung by serological assay of CEA (carcinoembryonic antigen); and (2) whether addition of seroassay of squamous cell carcinoma related antigen before treatment improves detection sensitivity. METHODS A prospective study spanning 27 months was conducted at the University Hospital, Kuala Lumpur. Serum CEA (Abbott IMx) and serum...

Objectives: To determine the pattern of histological findings in prostatic chips obtained from cases enlarged prostate gland and to correlate with PSA levels. Materials Methods: It was a cross sectional descriptive study conducted Northwest General Hospital , Peshawar 1st January 2018 23rd December 2021. A total 500 male features prostate, frequency, urgency dribbling mean age 52 ± 12.3 years (...

No effective tumor markers are available for squamous cell carcinoma of the head and neck region with the exception of immunosuppressive acidic protein (IAP). Recently, TA-4 was developed by Kato et al. as a marker of uterine cervical squamous cell carcinoma. Furthermore, squamous cell carcinoma related antigen (SCC antigen) was isolated from the tissue of liver metastasis of this carcinoma, an...

Prostatic intra-epithelial neoplasia (PIN) is considered a precursor of invasive carcinoma, characterized by proliferation and anaplasia of cells lining prostatic ducts and acini. In this study, we applied the PIN grading system on one-hundred cases of prostatic carcinoma and one-hundred cases of benign prostatic hyperplasia, then compared the results. 74% of prostatic carcinoma and 51 % of...

OBJECTIVE To investigate the possibility of objective clinical assessment of the radioresponse of cervical cancer via determination of serum squamous cell carcinoma antigen levels and magnetic resonance imaging (MRI)-based estimation of tumor shrinkage. METHODS The cases of 60 patients undergoing definitive radiotherapy for cervical squamous cell carcinoma (stage I-II: n = 20; stage III-IV: n...