T HAS BEEN SHOWN that cardiac glycosides inhibit the re-entry of potassium from the plasma into cold-stored erythrocytes and that the normal influx of potassium into the cells from the plasma of fresh blood incubated at 37#{176} can be almost abolished by the presence of cardiac glycosides (1). The normal efflux of potassium from the cells under these conditions is not inhibited and the cells s...

PREVious investigation by Simon, Bonting, and Hawkins (1962) indicated that intravenous cardiac glycosides caused a significant fall in the rate of aqueous humour formation in the cat eye. Langham (1963), using rabbits and cats, and Becker (1963), using rabbits, were not able to demonstrate this effect. Becker, using an intravitreal injection of cardiac glycosides, was able to demonstrate a fal...

Data relating to the use of digoxin from a descriptive epidemiological study of drug use in residential homes for elderly people were analysed. Of the 1,888 residents in the study homes, 212 were receiving cardiac glycosides. The ratio of females to males who received cardiac glycosides was 2.8:1; however, this was not statistically significant as it reflected the overall population. The median...

• The mechanisms by which cardiac glycosides increase the strength of the heartbeat are far from clear.Digitalis glycosides have no major influence on cell metabolism,*" nor on the contractile proteins. At sufficiently high concentrations they interfere with the movement of ions across cell membranes and it is tempting to assume that the inotropic action of glycosides is a consequence thereof.8...

The well known and accepted mode of action of cardiac glycosides is inhibition of the ubiquitous plasma membrane Na+, K+-ATPase that leads to increased intracellular Ca2+ ion concentrations. Ca2+ ions play pivotal role in many signaling pathways including those regulating apoptosis. It has been suggested that some forms of cardiac glycosides inhibit proliferation and induce apoptosis in prostat...

There are four isoforms of the alpha subunit (alpha1-4) and three isoforms of the beta subunit (beta1-3) of Na,K-ATPase, with distinct tissue-specific distribution and physiological functions. alpha2 is thought to play a key role in cardiac and smooth muscle contraction and be an important target of cardiac glycosides. An alpha2-selective cardiac glycoside could provide important insights into ...

The cardiac glycosides ouabain and digitoxin, established Na(+)/K(+) ATPase inhibitors, were found to inhibit MDA-MB-231 breast cancer cell migration through an unbiased chemical genetics screen for cell motility. The Na(+)/K(+) ATPase acts both as an ion-transporter and as a receptor for cardiac glycosides. To delineate which function is related to breast cancer cell migration, structure-activ...

Cardiac glycosides are potent inhibitors of cell division. They may be useful as antitumor agents if the antimitotic effect can be dissociated from their cardiotoxic effect. We studied congeners of cardiac glycosides to determine whether the saccharide or the genin portion of the molecule contributes to its antimitotic effect. The concentration of glycoside required to inhibit PHA-stimulated 3H...