نتایج جستجو برای: cartilage differentiation
تعداد نتایج: 255252 فیلتر نتایج به سال:
in vitro expansion of mesenchymal stem cell (mscs) into large number is necessary for their application in cell-based treatment of articular cartilage defects. on the other hand, some studies have indicated that bio (6-bromoindirubin-3-oxime) possesses mitogenic effects on cell culture. the objective of the present study was to examine the effect of bio on in vitro expansion and chondrogenic di...
background: hyaline cartilage defects exhibit a major challenge in the field of orthopedic surgery owing to its limited repair capacity. on the other hand, mesenchymal stem cells (mscs) are regarded as potent cells with a property of cartilage regeneration. we aimed to optimize marrow-derived msc chondrogenic culture using a small bioactive molecule referred to as bio. methods: mscs from the ma...
Purpose: Co-culture systems of marrow derived mesenchymal stem cells (mMSCs) with mature chondrocytes have theoretically been considered as a putative way of MSCs chondrogenic differentiation. MSCs differentiated in this system could be used for transplantation purpose without of any need to their purification since the cells with which MSCs are co cultured are native cartilage cells. Despite o...
hyaline cartilage is a vascular and neural tissue with scanty chondrocytes and limited regenerative ability. after some serious injuries of the cartilage, healing process will take place through the formation of fibrocartilage structures. currently, tissue engineering and cell therapy are 2 interesting therapeutic fields dealing with regenerative medicine. in this regard, tissue regeneration ha...
Purpose: Co-culture systems of marrow derived mesenchymal stem cells (mMSCs) with mature chondrocytes have theoretically been considered as a putative way of MSCs chondrogenic differentiation. MSCs differentiated in this system could be used for transplantation purpose without of any need to their purification since the cells with which MSCs are co cultured are native cartilage cells. Despite o...
Purpose: Dedifferentiation of the chondrocyte from rat articular cartilage with multiple subcultures and study of the redifferentiation potential of the cells into bone, cartilage and fat cell lineages. Materials and Methods: In this experimental study, chondrocytes from rat articular cartilage were isolated and expanded through several successive subcultures during which the expression levels ...
background: while articular chondrocytes are among those appropriate candidates for cartilage regeneration, the cell dedifferentiation during monolayer culture has limited their application. several investigations have indicated the usefulness of alginate, but the topic of proliferation and differentiation of chondrocytes in alginate culture has still remained controversial. methods: rat articu...
Background: While articular chondrocytes are among those appropriate candidates for cartilage regeneration, the cell dedifferentiation during monolayer culture has limited their application. Several investigations have indicated the usefulness of alginate, but the topic of proliferation and differentiation of chondrocytes in alginate culture has still remained controversial. Methods: Rat articu...
objective: cartilage mass produced from mesenchymal stem cell (msc) differentiation would be a suitable candidate for use in regenerative medicine. since the proper function of cartilage tissue is largely dependent on matrix glycosaminoglycan (gag) contents, the objective of this study was to investigate the enhancing effect of two gsk3 inhibitors on the gag content of cartilage produced by hum...
BACKGROUND/AIMS Joint cartilage defects are difficult to treat due to the limited self-repair capacities of cartilage. Cartilage tissue engineering based on stem cells and gene enhancement is a potential alternative for cartilage repair. Bone morphogenetic protein 2 (BMP2) has been shown to induce chondrogenic differentiation in mesenchymal stem cells (MSCs); however, maintaining the phenotypes...
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