T he health care profession and patients continue to await solid evidence about the effects of shark or bovine cartilage in the treatment of angiogenesis-dependent disease states, Some evidence has accrued that shark cartilage may have efficacy in several common diseases, including but not limited to cancer. Zealots have made unsubstantiated claims about the benefits of therapy with shark and o...

This works presents a robust methodology for the analysis of the knee joint cartilage and the knee bone-cartilage interface from fused MRI sets. The proposed approach starts by fusing a set of two 3D MR images the knee. Although the proposed method is not pulse sequence dependent, the first sequence should be programmed to achieve good contrast between bone and cartilage. The recommended second...

OF THE THESIS IN VITRO EFFECT OF SHARK CARTILAGE ON HUMAN LEUKOCYTE FUNCTION by Aline Comelissen Florida International University, 2001 Miami, Florida Professor Sylvia L. Smith, Major Professor Previous in vitro studies have shown that shark cartilage extracts stimulate human leukocytes to release significant levels of TNFa, a cytokine typical of a Thl immune response. The purpose of this study...

introduction: oxidative stress has been implicated in the pathogenesis of various diseases affecting chondrogenesis or the function of articular cartilage. the purpose of the present study was to find the effect of soybean extract on reduction of detoriation effects of oxidativestress in embryonic chondrogenesis in vitro. methods: in order to separate ectoderm from mesenchyme, the limb buds of ...

Alflutop is the standardized sterile extract of marine fish, similar in composition to matrix hyaline cartilage, manufactured by Biotehnos S.A. (Romania). The question effectiveness aflutop remains relevant.

Type IX collagen, a quantitatively minor collagenous component of cartilage, is known to be associated with and covalently cross-linked to type II collagen fibrils in chick and bovine cartilage. Type IX collagen molecules have also been shown to form covalent cross-links with each other in bovine cartilage. In the present study we demonstrate by structural analysis and location of cross-linking...

Introduction: Oxidative stress has been implicated in the pathogenesis of various diseases affecting chondrogenesis or the function of articular cartilage. The purpose of the present study was to find the effect of soybean extract on reduction of detoriation effects of oxidativestress in embryonic chondrogenesis in vitro. Methods: In order to separate ectoderm from mesenchyme, the limb buds ...

We describe a method to detect osteoarthritis (OA) from knee X-ray images. The detection is based on the thickness of cartilage in knee bone, which correspond to possibility of osteoarthritis. Using our approach better diagnosis treatment can be applied to the patient since a computed automated measurements leads to accurate values so the image segmentation and mathematical morphological operat...

Extracts of human articular cartilage contain proteases capable of degrading the proteoglycan component of cartilage matrix at neutral and acid pH. These enzymes have been partially purified by ion exchange chromotography and characterized by disc electrophoresis, inhibition patterns, and action of proteoglycan. Three distinct metalloproteases are described. A neutral protease that digests prot...

An in vitro system has been developed to study the onset of chondrogenesis. Embryonic rat muscle mesenchymal cells, when treated in suspension culture with an extract of bovine bone matrix, synthesized cartilage-specific proteoglycan and type II collagen. The synthesis of these two macromolecules was assayed by the enzyme-linked immunosorbent assay inhibition technique. Further evidence of chon...