introduction: exposure to 3-4, methylenedioxymethamphetamine (mdma) leads to cell death. herein, we studied the protective effects of ginger on mdma- induced apoptosis. methods: 15 sprague dawley male rats were administrated with 0, 10 mg/kg mdma, or mdma along with 100mg/kg ginger, ip for 7 days. brains were removed to study the caspase 3, 8, and 9 expressions in the hippocampus by rt-pcr. dat...

Abstract Background Apoptosis is an important process for organism’s innate immune system to respond pathogens, while also allowing cell differentiation and other essential life functions. Caspases are one of the key protease enzymes involved in apoptotic process, however there currently a very limited understanding bivalve caspase diversity function. Results In this work, we investigated prese...

Objective(s):  Apoptosis is a tightly regulated process and plays a crucial role in autoimmune diseases. Because abnormalities in apoptosis are considered to be involved in the pathogenesis of systemic lupus erythematosus (SLE), in present study we studied the apoptosis in T lymphocytes from Iranian SLE patientsat protein and gene expression levels for some molecules which are involved in apopt...

Photodynamic therapy (PDT) is an innovative and perspective antineoplastic therapy. Tetra-α-(4-carboxyphenoxy) phthalocyanine zinc (TαPcZn)-mediated PDT (TαPcZn-PDT) has shown antitumor activity in some tumor cells, but the manner which caspase-1 involved regulation of apoptosis pyroptosis TαPcZn-PDT-treated breast cancer MCF-7 cells unclear. Therefore, effects TαPcZn-PDT on cytotoxicity, cell ...

The aim of this study was to investigate the activity apoptosis and autophagy in animals (cows, horses, donkeys, dogs cats) naturally infected with rabies by using immunohistochemistry, immunofluorescence, qPCR. mRNA transcript levels caspase-3, Bax, Bcl2 LC3B were determined Caspase-3 AIF immunopositivity not observed immunohistochemical immunofluorescence staining, whereas intensively compare...

objective(s):several investigations have revealed that caspase-14 is responsible for the epidermal differentiation and cornification, as well as the regulation of moisturizing effect. however, the precise regulation mechanism is still not clear. this study was aimed to investigate the expression of caspase-14 in filaggrin-deficient normal human epidermal keratinocytes (nheks) and to explore the...

salvia chorassanica bunge is one of the iranian endemic species of salvia. there is not any reported literature on s. chorassanica. this study was designed to examine the in-vitro anti-proliferative and proapoptotic effects of the methanol extract of s. chorassanica and its fractions on hela cell line. cells were cultured in ex-cell®, an animal free medium specially designed for hela cell line ...

caspase-3, one of the dominant effectors caspases, is activated in almost every model of apoptosis with various signaling pathways. hence, inhibition of caspase-3 has become an attractive target in the treatment of neurodegenerative diseases. caspase-3 inhibitory activities of some 1,2-benzisothiazol-3-one derivatives were modeled by quantitative structure–activity relationship (qsar) using ste...

mono-targeting by imatinib as a main antitumor agent does not always accomplish complete cancer suppression. 2,5-dimethyl-celecoxib (dmc) is a close structural analog of the selective cyclooxygenase-2 (cox-2) inhibitor, celecoxib, that lacks cox-2 inhibitory function. in this study, we aimed to show the apoptotic effects of imatinib in combination with dmc in human ht-29 colorectal cancer (crc)...

Objective(s):Several investigations have revealed that caspase-14 is responsible for the epidermal differentiation and cornification, as well as the regulation of moisturizing effect. However, the precise regulation mechanism is still not clear. This study was aimed to investigate the expression of caspase-14 in filaggrin-deficient normal human epidermal keratinocytes (NHEKs) and to explore the...