The relation between men and women suffering pulmonary tuberculosis is 7/3 in favor to males. Sex hormones could be a significant factor for this difference, considering that testosterone impairs macrophage activation and pro-inflammatory cytokines production, while estrogens are proinflammatory mediator's inducer. The aim of this work was to compare the evolution of tuberculosis in male and fe...

In utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure inhibits ventral, dorsolateral, and anterior prostate development in C57BL/6 mice. To determine if prostatic abnormalities persist into senescence, mice born to dams given TCDD (5 mug/kg, po) or vehicle on gestation day 13 were examined at 100 and 510 days of age. Half the mice were castrated ten days prior to necropsy...

Low vitamin D (VD) status may increase prostate cancer risk but experimental evidence for this relationship is modest. We tested whether low VD status or VD receptor (VDR) deletion influences prostate epithelial cell (PEC) biology using intact mice, castrated mice, or castrated mice treated with testosterone propionate (TP, 2.5 mg/kg BW). PEC proliferation (Ki-67 staining) and apoptosis (TUNEL ...

The effect of an indigenous drug, Speman, on the accessory reproductive organs was observed on castrated adult mice and on immature intact mice. The dose related growth of ventral prostate and the systemic increase in the weights as well as the secretions of accessory sex organs of the castrated adults treated with Speman indicated that the drug possessed anabolic-cum-androgen like activity

The behavioural assays were carried out in a Y-maze wherein intact, castrated and testosterone-treated male mice were exposed to oestrus and non-oestrus urine samples. The intact male mice investigated more frequently and spent more time in the Y-maze arm with oestrus urine than in that with non-oestrus urine. In contrast, the castrated mice were not attracted to oestrus urine, whereas testoste...

Antibodies to native DNA and to polyadenylic acid (Poly A) occur spontaneously and undergo a regulated switch from IgM to IgG during the course of autoimmune disease in NZB/NZW F(1) (B/W) mice. B/W females have higher titers and earlier commitment to 7S antibodies to DNA and Poly A, whereas B/W males bind DNA and Poly A primarily by 19S antibodies. We have performed castration experiments to de...

We investigated histochemically the expression of glycans in the mouse ventral prostate of the normal, castrated, castrated mice injected with testosterone (T) and castrated mice injected with dihydrotestosterone (DHT). The avidin-biotinperoxidase complex technique was used with eight biotinylated lectins, on paraffin sections. Remarkably, contrarily to T, the DHT found to restore all the glyca...

The work of Loeb (21, 22), Cori (6, 9) and Murray (23, 24) demonstrated that ovariectomy of mice in certain stocks at an early age was associated with a reduction in incidence of spontaneous mammary tumors. Hyperplasia and/or adenoma of the adrenal cortical cells in castrated male and female mice was later described in several inbred stocks (dba, ce, C3H, CBA, NH, Balb) (13, 14, 27, 29). The al...

Recent studies suggest beneficial effects of castration before soft tissue trauma and hemorrhagic shock on splenocyte immune functions. Nonetheless, it remains unknown whether this effect of testosterone depletion is limited to splenocytes or is a generalized effect on immune function. The present study was therefore carried out to determine whether androgen depletion before trauma-hemorrhage a...

The most appropriate time to introduce androgen deprivation therapy for prostate cancer remains controversial. Our aim was to evaluate the effects of early versus delayed surgical castration on prostate cancer progression and survival in the transgenic adenocarcinoma of the mouse prostate (TRAMP) model. TRAMP mice were randomly divided into three groups: the early castration group (on which cas...