Background: Molecular marker based cancer diagnosis gaining more attention in the current genomics era. So, Hspb1 and Tp53 gene characterization and their mRNA expression might be helpful in diagnosis andprognosis ofcat mammary adenocarcinoma. It will also add informationin comparative cancer genetics and genomics. Objectives: Eight tumors of Siamese cats were analyzed to ascertain germ-line an...

The present report describes a giant cell type of malignant fibrous histiocytoma (MFH), diagnosed in soft parts of the right abdominal mammary region, in an 11-year old, 8 kg, nulliparous female Ankara (Angora) cat diagnosed in soft parts of the right abdominal mammary region. The tumor, surgically excised from the abdominal region, had a flexible consistency with ulcerated overlying skin. The ...

objective: n-nitroso-n-methylurea (nmu) induces breast cancer in rodents, particularly in rats. this model of breast cancer is very similar to human breast cancer. as a continuation of our recent work, we investigated the expressions of cyclin d1 and p21 in nmu-induced breast cancer of wistar albino rats. materials and methods: in this experimental study, mammary carcinoma was induced in female...

Feline mammary tumor is a relatively commonly diagnosed neoplasm in the cat. Development of new veterinary cancer therapies limited by shortage vivo models that reproduce microenvironment and metastatic progression. Four feline orthotopic patient-derived xenograft model (PDX) successfully established NOD-SCID gamma (NSG) mice. The overall success rate PDX establishment was 36% (4/11). Histologi...

Mammary cancer is the third most common cancer in the cat. The average age of cats presenting with mammary tumors is 10-12 years. Siamese cats appear to have twice the risk of developing mammary cancers than other breeds. Recent studies suggest that spayed female cats have a 40-60% lower risk of mammary cancer than intact females. There is a strong association with the use of synthetic progesti...

Mammary cancer is the third most common cancer in the cat. The average age of cats presenting with mammary tumors is 10-12 years. Siamese cats appear to have twice the risk of developing mammary cancers than other breeds. Recent studies suggest that spayed female cats have a 40-60% lower risk of mammary cancer than intact females. There is a strong association with the use of synthetic progesti...

Obesity is an established risk factor for breast cancer in post-menopausal women, being associated with elevated serum levels of leptin. Although overweight a common condition cat, the role leptin and its receptor feline mammary carcinoma remains unsettled. In this study, (ObR) were investigated 58 cats compared those healthy animals, as expression ObR tumor tissues. The results showed that Fre...

A fibroadenoma was diagnosed in the mammary gland of a lamb by immunohistochemical method andmeasurement of oestradiol hormone. The tumor was characterized by an encapsulated firm mass with acreamy-white cut surface. Histologically, it consisted of variably-sized sinus ducts, covered by a single ormultiple layers of proliferated epithelial cells, and embedded in a loose connective tissue. Immun...

Vitásek R. , H. Dendisová: Treatment of Feline Mammary Fibroepithelial Hyperplasia Following a Single Injection of Proligestone. Acta Vet. Brno 2006, 75: 295-297. A case of fibroepithelial hyperplasia of the mammary gland in the cat is reported. A seven-monthold female cat was presented for diffuse enlargement of all of the mammary glands. The cat was treated with proligestone (Covinan®) for th...