INTRODUCTION The endocannabinoid system is composed of endogenous ligands, their enzymes for biosynthesis and degradation and cannabinoid receptors (13). The CB1 receptor is one of the most abundant G protein-coupled receptors expressed in the central nervous system (5). The regional distribution of CB1 receptors has been described in the rat brain (10, 15). During aging the number of CB1 recep...

The intestinal hormone cholecystokinin (CCK) inhibits food intake via stimulation of vagal afferent neurons (VAN). Recent studies suggest that CCK also regulates the expression of some G protein-coupled receptors and neuropeptide transmitters in these neurons. The aim of the present study was to characterize the expression of cannabinoid (CB)1 receptors in VAN and to determine whether stimulati...

Introduction: Previous studies have shown that the basolateral amygdale (BLA) is rich of CB1 cannabinoid receptors and involved in cannabinoid-induced antinociception. Also, it seems that there are functional interactions between the cannabinoid CB1 and opioid receptors in the process of sensitization to opiates. In the present study, we tried to examine the role of intra-BLA cannabinoid rece...

introduction: previous studies have shown that the basolateral amygdale (bla) is rich of cb1 cannabinoid receptors and involved in cannabinoid-induced antinociception. also, it seems that there are functional interactions between the cannabinoid cb1 and opioid receptors in the process of sensitization to opiates. in the present study, we tried to examine the role of intra-bla cannabinoid recept...

Cannabinoid CB1 receptors have been detected in retinas of numerous species, with prominent labeling in photoreceptor terminals of the chick and monkey. CB1 labeling is well-conserved across species, suggesting that CB1 receptors might also be present in photoreceptors of the tiger salamander. Synaptic transmission in vertebrate photoreceptors is mediated by L-type calcium currents-currents tha...

Effects of cannabinoids (CBs) are mediated by two types of receptors, CB1 and CB2. In this report, we investigated whether CBs regulate gene expression of their cognate receptors in T cells and studied underlying mechanisms in CD4+ Jurkat T cells. Transcription of the CB1 gene was strongly induced in response to Delta9-tetrahydrocannabinol (THC), whereas the CB2 gene was not regulated. The indu...

endocannabinoid (ecb) system plays a vital role in responses to stress. moreover, ecb and its receptors cause anti-inflammatory, anti-oxidative and neuroprotective effects by modulating neuronal, glial and endothelial cell functions. a number of studies have demonstrated ecb system notably defects in neurotraumatic and neurodegenerative diseases like epilepsy, tbi, alzheimer’s disease and parki...

AIM The localization of CB1 receptors in the spinal cord, spinal roots, dorsal root ganglion (DRG), and peripheral nerve of the rat was determined. METHODS We studied the distribution of CB1 cannabinoid receptors by immunohistochemistry using an antibody raised against the N-terminal of the receptor. RESULTS The spinal cord showed numerous transverse fibers labelled for CB1 receptors throug...

Two types of cannabinoid receptor have so far been identified.1,2 These are the CB1 receptor, cloned in 1990,3 and the CB2 receptor, cloned in 1993,4 both of which are members of the superfamily of G-protein-coupled receptors. The cloning of these receptors prompted the development of mice from which cannabinoid CB1 and/or CB2 receptors have been genetically deleted and these transgenic animals...

objective (s):hyperglycemia is widely recognized as the underlying cause for some debilitating conditions in diabetic patients. the role of cannabinoid cb1 and vanilloid trpv1 receptors and their endogenous agonists, endovanilloids, in diabetic neuropathy is shown in many studies. here we have used pc12 cell line to investigate the possible influence of glucose concentration in culture medium o...