An integrated approach is presented, in which a primarily case-based reasoning (CBR) system for nutritional menu design is enhanced by rule-based reasoning (RBR). In nutritional menu planning, a nutritionist plans a daily menu for a single individual, taking dietary requirements and personal preferences into account. This task requires satisfaction of multiple numeric nutrition constraints plus...

OBJECTIVE To evaluate the efficacy and tolerability of letrozole plus lapatinib versus letrozole plus placebo in women with hormone receptor (HR)(+) human epidermal growth factor receptor (HER)-2(+) tumors receiving first-line therapy for metastatic breast cancer (MBC). PATIENTS AND METHODS Postmenopausal women (n = 1,286) with HR(+) MBC were randomized to daily oral treatment with letrozole ...

The aim of the present study was to assess the efficacy and tolerability of a luteinizing hormone-releasing hormone (LH-RH) analogue plus an aromatase inhibitor following failure to respond to standard LH-RH analogue plus tamoxifen (TAM) in premenopausal patients. Premenopausal women with estrogen receptor (ER)-positive and/or progesterone-receptor positive, advanced or recurrent breast cancer ...

Artificial Intelligence algorithms can be divided into two groups according to the type of problems they solve. Knowledge-intensive domains contain explicit knowledge, whereas knowledge-poor domains contain implicit knowledge. Logical methods are more suitable for the first type. Neural networks and case-based reasoning (CBR) are more suitable for the second type. This project combines the infe...

UNLABELLED In an effort to clarify the mechanism of action of isoflurane, we studied the effect of flumazenil on mice chronically treated with isoflurane or diazepam. Mice were pretreated with diazepam, isoflurane, or saline, with and without flumazenil. After 2 wk, responses to isoflurane and diazepam were assessed, and central benzodiazepine receptor (CBR) binding characteristics were assayed...

The task of designing nutritious, yet appetizing, menus is one at which human experts consistently outperform computer systems. Tailoring a menu to the needs of an individual requires satisfaction of multiple numeric nutrition constraints plus personal preference goals and aesthetic criteria. We have combined case-based reasoning (CBR) and rule-based reasoning (RBR) in a hybrid system which des...